RRM2B
| Ribonucleotide reductase M2 B (TP53 inducible) | |||||||||||
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| Identifiers | |||||||||||
| Symbols | RRM2B ; DKFZp686M05248; MGC102856; MGC42116; p53R2 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 56723 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE RRM2B gnf1h06036 at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Ribonucleotide reductase M2 B (TP53 inducible), also known as RRM2B, is a human gene.[1]
References
Further reading
- Tanaka H, Arakawa H, Yamaguchi T; et al. (2000). "A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage". Nature. 404 (6773): 42–9. doi:10.1038/35003506. PMID 10716435.
- Nakano K, Bálint E, Ashcroft M, Vousden KH (2000). "A ribonucleotide reductase gene is a transcriptional target of p53 and p73". Oncogene. 19 (37): 4283–9. PMID 10980602.
- Guittet O, Håkansson P, Voevodskaya N; et al. (2001). "Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells". J. Biol. Chem. 276 (44): 40647–51. doi:10.1074/jbc.M106088200. PMID 11517226.
- Yamaguchi T, Matsuda K, Sagiya Y; et al. (2001). "p53R2-dependent pathway for DNA synthesis in a p53-regulated cell cycle checkpoint". Cancer Res. 61 (22): 8256–62. PMID 11719458.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Yanamoto S, Kawasaki G, Yoshitomi I, Mizuno A (2003). "Expression of p53R2, newly p53 target in oral normal epithelium, epithelial dysplasia and squamous cell carcinoma". Cancer Lett. 190 (2): 233–43. PMID 12565178.
- Xue L, Zhou B, Liu X; et al. (2003). "Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits". Cancer Res. 63 (5): 980–6. PMID 12615712.
- Zhou B, Liu X, Mo X; et al. (2003). "The human ribonucleotide reductase subunit hRRM2 complements p53R2 in response to UV-induced DNA repair in cells with mutant p53". Cancer Res. 63 (20): 6583–94. PMID 14583450.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Shao J, Zhou B, Zhu L; et al. (2004). "In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase". Cancer Res. 64 (1): 1–6. PMID 14729598.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Ceballos E, Muñoz-Alonso MJ, Berwanger B; et al. (2005). "Inhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells. Microarray analysis reveals defective induction of p53 target genes and upregulation of chaperone genes". Oncogene. 24 (28): 4559–71. doi:10.1038/sj.onc.1208652. PMID 15856024.
- Deng ZL, Xie DW, Bostick RM; et al. (2005). "Novel genetic variations of the p53R2 gene in patients with colorectal adenoma and controls". World J. Gastroenterol. 11 (33): 5169–73. PMID 16127747.
- Ohno K, Tanaka-Azuma Y, Yoneda Y, Yamada T (2006). "Genotoxicity test system based on p53R2 gene expression in human cells: examination with 80 chemicals". Mutat. Res. 588 (1): 47–57. doi:10.1016/j.mrgentox.2005.09.002. PMID 16236544.
- Qiu W, Zhou B, Darwish D; et al. (2006). "Characterization of enzymatic properties of human ribonucleotide reductase holoenzyme reconstituted in vitro from hRRM1, hRRM2, and p53R2 subunits". Biochem. Biophys. Res. Commun. 340 (2): 428–34. doi:10.1016/j.bbrc.2005.12.019. PMID 16376858.
- Okumura H, Natsugoe S, Yokomakura N; et al. (2006). "Expression of p53R2 is related to prognosis in patients with esophageal squamous cell carcinoma". Clin. Cancer Res. 12 (12): 3740–5. doi:10.1158/1078-0432.CCR-05-2416. PMID 16778101.
- Yen Y, Chu B, Yen C; et al. (2007). "Enzymatic property analysis of p53R2 subunit of human ribonucleotide reductase". Adv. Enzyme Regul. 46: 235–47. doi:10.1016/j.advenzreg.2006.01.016. PMID 16846634.
- Lembo D, Donalisio M, Cornaglia M; et al. (2007). "Effect of high-risk human papillomavirus oncoproteins on p53R2 gene expression after DNA damage". Virus Res. 122 (1–2): 189–93. doi:10.1016/j.virusres.2006.06.011. PMID 16872707.
- Bourdon A, Minai L, Serre V; et al. (2007). "Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion". Nat. Genet. 39 (6): 776–80. doi:10.1038/ng2040. PMID 17486094.
- Yokomakura N, Natsugoe S, Okumura H; et al. (2007). "Improvement in radiosensitivity using small interfering RNA targeting p53R2 in esophageal squamous cell carcinoma". Oncol. Rep. 18 (3): 561–7. PMID 17671702.
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