RICTOR
| Rapamycin-insensitive companion of mTOR | |||||
|---|---|---|---|---|---|
| Identifiers | |||||
| Symbols | RICTOR ; DKFZp686B11164; KIAA1999; MGC39830; mAVO3 | ||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 34317 | ||||
| |||||
| RNA expression pattern | |||||
| File:PBB GE RICTOR gnf1h04394 at tn.png | |||||
| More reference expression data | |||||
| Orthologs | |||||
| Template:GNF Ortholog box | |||||
| Species | Human | Mouse | |||
| Entrez | n/a | n/a | |||
| Ensembl | n/a | n/a | |||
| UniProt | n/a | n/a | |||
| RefSeq (mRNA) | n/a | n/a | |||
| RefSeq (protein) | n/a | n/a | |||
| Location (UCSC) | n/a | n/a | |||
| PubMed search | n/a | n/a | |||
Rapamycin-insensitive companion of mTOR, also known as RICTOR, is a human gene.[1]
RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004).[supplied by OMIM][1]
References
Further reading
- Cohen D, Scribner R, Clark J, Cory D (1992). "The potential role of custody facilities in controlling sexually transmitted diseases". American journal of public health. 82 (4): 552–6. PMID 1546771.
- Ohara O, Nagase T, Mitsui G; et al. (2003). "Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method". DNA Res. 9 (2): 47–57. PMID 12056414.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Sarbassov DD, Ali SM, Kim DH; et al. (2004). "Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton". Curr. Biol. 14 (14): 1296–302. doi:10.1016/j.cub.2004.06.054. PMID 15268862.
- Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
- Jacinto E, Loewith R, Schmidt A; et al. (2004). "Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive". Nat. Cell Biol. 6 (11): 1122–8. doi:10.1038/ncb1183. PMID 15467718.
- Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (2005). "Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex". Science. 307 (5712): 1098–101. doi:10.1126/science.1106148. PMID 15718470.
- Kudchodkar SB, Yu Y, Maguire TG, Alwine JC (2006). "Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes". Proc. Natl. Acad. Sci. U.S.A. 103 (38): 14182–7. doi:10.1073/pnas.0605825103. PMID 16959881.
- Jacinto E, Facchinetti V, Liu D; et al. (2006). "SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity". Cell. 127 (1): 125–37. doi:10.1016/j.cell.2006.08.033. PMID 16962653.
- Yang Q, Inoki K, Ikenoue T, Guan KL (2006). "Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity". Genes Dev. 20 (20): 2820–32. doi:10.1101/gad.1461206. PMID 17043309.
- Fuchs BC, Finger RE, Onan MC, Bode BP (2007). "ASCT2 silencing regulates mammalian target-of-rapamycin growth and survival signaling in human hepatoma cells". Am. J. Physiol., Cell Physiol. 293 (1): C55–63. doi:10.1152/ajpcell.00330.2006. PMID 17329400.
- Pearce LR, Huang X, Boudeau J; et al. (2007). "Identification of Protor as a novel Rictor-binding component of mTOR complex-2". Biochem. J. 405 (3): 513–22. doi:10.1042/BJ20070540. PMID 17461779.
 | This protein-related article is a stub. You can help Wikipedia by expanding it. |