PRDX5

Peroxiredoxin 5
File:PBB Protein PRDX5 image.jpg PDB rendering based on 1h4o.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1h4o​, 1hd2​, 1oc3​, 1urm​
Identifiers
Symbols	PRDX5 ; PLP; PRDX6; ACR1; AOEB166; B166; MGC117264; MGC142283; MGC142285; PMP20; PRXV; SBBI10
External IDs	Template:OMIM5 Template:MGI HomoloGene: 8076
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Peroxiredoxin 5, also known as PRDX5, is a human gene.

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. This protein interacts with peroxisome receptor 1. The crystal structure of this protein in its reduced form has been resolved to 1.5 angstrom resolution. This gene uses alternate in-frame translation initiation sites to generate mitochondrial or peroxisomal/cytoplasmic forms. Three transcript variants encoding distinct isoforms have been identified for this gene.

Further reading

• Wood ZA, Schröder E, Robin Harris J, Poole LB (2003). "Structure, mechanism and regulation of peroxiredoxins". Trends Biochem. Sci. 28 (1): 32–40. PMID 12517450.CS1 maint: Multiple names: authors list (link)
• Hochstrasser DF, Frutiger S, Paquet N; et al. (1993). "Human liver protein map: a reference database established by microsequencing and gel comparison". Electrophoresis. 13 (12): 992–1001. PMID 1286669.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kropotov A, Sedova V, Ivanov V; et al. (1999). "A novel human DNA-binding protein with sequence similarity to a subfamily of redox proteins which is able to repress RNA-polymerase-III-driven transcription of the Alu-family retroposons in vitro". Eur. J. Biochem. 260 (2): 336–46. PMID 10095767.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wattiez R, Hermans C, Bernard A; et al. (1999). "Human bronchoalveolar lavage fluid: two-dimensional gel electrophoresis, amino acid microsequencing and identification of major proteins". Electrophoresis. 20 (7): 1634–45. doi:10.1002/(SICI)1522-2683(19990601)20:7<1634::AID-ELPS1634>3.0.CO;2-J. PMID 10424490.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamashita H, Avraham S, Jiang S; et al. (1999). "Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro". J. Biol. Chem. 274 (42): 29897–904. PMID 10514471.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Knoops B, Clippe A, Bogard C; et al. (1999). "Cloning and characterization of AOEB166, a novel mammalian antioxidant enzyme of the peroxiredoxin family". J. Biol. Chem. 274 (43): 30451–8. PMID 10521424.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhou Y, Kok KH, Chun AC; et al. (2000). "Mouse peroxiredoxin V is a thioredoxin peroxidase that inhibits p53-induced apoptosis". Biochem. Biophys. Res. Commun. 268 (3): 921–7. doi:10.1006/bbrc.2000.2231. PMID 10679306.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Seo MS, Kang SW, Kim K; et al. (2000). "Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate". J. Biol. Chem. 275 (27): 20346–54. doi:10.1074/jbc.M001943200. PMID 10751410.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hu RM, Han ZG, Song HD; et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMID 10931946.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Declercq JP, Evrard C, Clippe A; et al. (2001). "Crystal structure of human peroxiredoxin 5, a novel type of mammalian peroxiredoxin at 1.5 A resolution". J. Mol. Biol. 311 (4): 751–9. doi:10.1006/jmbi.2001.4853. PMID 11518528.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rouhier N, Gelhaye E, Jacquot JP (2002). "Glutaredoxin-dependent peroxiredoxin from poplar: protein-protein interaction and catalytic mechanism". J. Biol. Chem. 277 (16): 13609–14. doi:10.1074/jbc.M111489200. PMID 11832487.CS1 maint: Multiple names: authors list (link)
• Wang MX, Wei A, Yuan J; et al. (2002). "Expression and regulation of peroxiredoxin 5 in human osteoarthritis". FEBS Lett. 531 (2): 359–62. PMID 12417342.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Leyens G, Donnay I, Knoops B (2004). "Cloning of bovine peroxiredoxins-gene expression in bovine tissues and amino acid sequence comparison with rat, mouse and primate peroxiredoxins". Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 136 (4): 943–55. PMID 14662316.CS1 maint: Multiple names: authors list (link)
• Banmeyer I, Marchand C, Verhaeghe C; et al. (2004). "Overexpression of human peroxiredoxin 5 in subcellular compartments of Chinese hamster ovary cells: effects on cytotoxicity and DNA damage caused by peroxides". Free Radic. Biol. Med. 36 (1): 65–77. doi:10.1016/j.freeradbiomed.2003.10.019. PMID 14732291.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Salmon M, Dedessus Le Moutier J, Wenders F; et al. (2004). "Role of the PLA2-independent peroxiredoxin VI activity in the survival of immortalized fibroblasts exposed to cytotoxic oxidative stress". FEBS Lett. 557 (1–3): 26–32. PMID 14741336.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Evrard C, Capron A, Marchand C; et al. (2004). "Crystal structure of a dimeric oxidized form of human peroxiredoxin 5". J. Mol. Biol. 337 (5): 1079–90. doi:10.1016/j.jmb.2004.02.017. PMID 15046979.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yuan J, Murrell GA, Trickett A; et al. (2004). "Overexpression of antioxidant enzyme peroxiredoxin 5 protects human tendon cells against apoptosis and loss of cellular function during oxidative stress". Biochim. Biophys. Acta. 1693 (1): 37–45. doi:10.1016/j.bbamcr.2004.04.006. PMID 15276323.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dubuisson M, Vander Stricht D, Clippe A; et al. (2004). "Human peroxiredoxin 5 is a peroxynitrite reductase". FEBS Lett. 571 (1–3): 161–5. doi:10.1016/j.febslet.2004.06.080. PMID 15280035.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)