PIK3CB

Phosphoinositide-3-kinase, catalytic, beta polypeptide
Identifiers
Symbols	PIK3CB ; PI3K; DKFZp779K1237; MGC133043; PI3Kbeta; PIK3C1; p110-BETA
External IDs	Template:OMIM5 Template:MGI HomoloGene: 21250
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PIK3CB 212688 at tn.png
File:PBB GE PIK3CB 217620 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Phosphoinositide-3-kinase, catalytic, beta polypeptide, also known as PIK3CB, is a human gene.

Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. They have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kD catalytic subunit, such as PIK3CB, and an 85-kD adaptor subunit (Hu et al., 1993).[supplied by OMIM]

Further reading

• Katada T, Kurosu H, Okada T; et al. (1999). "Synergistic activation of a family of phosphoinositide 3-kinase via G-protein coupled and tyrosine kinase-related receptors". Chem. Phys. Lipids. 98 (1–2): 79–86. PMID 10358930.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee C, Liu QH, Tomkowicz B; et al. (2004). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". J. Leukoc. Biol. 74 (5): 676–82. doi:10.1189/jlb.0503206. PMID 12960231.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Carpenter CL, Duckworth BC, Auger KR; et al. (1991). "Purification and characterization of phosphoinositide 3-kinase from rat liver". J. Biol. Chem. 265 (32): 19704–11. PMID 2174051.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonnefoy-Bérard N, Liu YC, von Willebrand M; et al. (1995). "Inhibition of phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells". Proc. Natl. Acad. Sci. U.S.A. 92 (22): 10142–6. PMID 7479742.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hu P, Schlessinger J (1994). "Direct association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 beta". Mol. Cell. Biol. 14 (4): 2577–83. PMID 8139559.
• Hu P, Mondino A, Skolnik EY, Schlessinger J (1994). "Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85". Mol. Cell. Biol. 13 (12): 7677–88. PMID 8246984.CS1 maint: Multiple names: authors list (link)
• Milani D, Mazzoni M, Borgatti P; et al. (1996). "Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells". J. Biol. Chem. 271 (38): 22961–4. PMID 8798481.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mazerolles F, Barbat C, Fischer A (1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity". Eur. J. Immunol. 27 (9): 2457–65. PMID 9341793.CS1 maint: Multiple names: authors list (link)
• Borgatti P, Zauli G, Colamussi ML; et al. (1998). "Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells". Eur. J. Immunol. 27 (11): 2805–11. PMID 9394803.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Borgatti P, Zauli G, Cantley LC, Capitani S (1998). "Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells". Biochem. Biophys. Res. Commun. 242 (2): 332–7. PMID 9446795.CS1 maint: Multiple names: authors list (link)
• Milani D, Mazzoni M, Zauli G; et al. (1998). "HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells". AIDS. 12 (11): 1275–84. PMID 9708406.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jauliac S, Mazerolles F, Jabado N; et al. (1998). "Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity". Eur. J. Immunol. 28 (10): 3183–91. PMID 9808187.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Graness A, Adomeit A, Heinze R; et al. (1998). "A novel mitogenic signaling pathway of bradykinin in the human colon carcinoma cell line SW-480 involves sequential activation of a Gq/11 protein, phosphatidylinositol 3-kinase beta, and protein kinase Cepsilon". J. Biol. Chem. 273 (48): 32016–22. PMID 9822674.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sotsios Y, Whittaker GC, Westwick J, Ward SG (1999). "The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes". J. Immunol. 163 (11): 5954–63. PMID 10570282.CS1 maint: Multiple names: authors list (link)
• Park IW, Wang JF, Groopman JE (2001). "HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes". Blood. 97 (2): 352–8. PMID 11154208.CS1 maint: Multiple names: authors list (link)
• Zauli G, Milani D, Mirandola P; et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang H, Wang X, Raizada MK (2001). "Characterization of signal transduction pathway in neurotropic action of angiotensin II in brain neurons". Endocrinology. 142 (8): 3502–11. PMID 11459796.CS1 maint: Multiple names: authors list (link)
• Steták A, Csermely P, Ullrich A, Kéri G (2001). "Physical and functional interactions between protein tyrosine phosphatase alpha, PI 3-kinase, and PKCdelta". Biochem. Biophys. Res. Commun. 288 (3): 564–72. doi:10.1006/bbrc.2001.5811. PMID 11676480.CS1 maint: Multiple names: authors list (link)
• Ueki K, Yballe CM, Brachmann SM; et al. (2002). "Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 419–24. doi:10.1073/pnas.012581799. PMID 11752399.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)