NOX5

NADPH oxidase, EF-hand calcium binding domain 5
Identifiers
Symbols	NOX5 ; MGC149776; MGC149777; NOX5A; NOX5B
External IDs	Template:OMIM5 HomoloGene: 41568
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE NOX5 220641 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

NADPH oxidase, EF-hand calcium binding domain 5, also known as NOX5, is a human gene.

NOX5 is a novel NADPH oxidase that generates superoxide and functions as a H+ channel in a Ca(2+)-dependent manner.[supplied by OMIM]

Further reading

• Lachgar A, Sojic N, Arbault S; et al. (1999). "Amplification of the inflammatory cellular redox state by human immunodeficiency virus type 1-immunosuppressive tat and gp160 proteins". J. Virol. 73 (2): 1447–52. PMID 9882350.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cheng G, Cao Z, Xu X; et al. (2001). "Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5". Gene. 269 (1–2): 131–40. PMID 11376945.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bánfi B, Molnár G, Maturana A; et al. (2001). "A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes". J. Biol. Chem. 276 (40): 37594–601. doi:10.1074/jbc.M103034200. PMID 11483596.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Armstrong JS, Bivalacqua TJ, Chamulitrat W; et al. (2002). "A comparison of the NADPH oxidase in human sperm and white blood cells". Int. J. Androl. 25 (4): 223–9. PMID 12121572.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moskwa P, Dagher MC, Paclet MH; et al. (2002). "Participation of Rac GTPase activating proteins in the deactivation of the phagocytic NADPH oxidase". Biochemistry. 41 (34): 10710–6. PMID 12186557.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bánfi B, Tirone F, Durussel I; et al. (2004). "Mechanism of Ca2+ activation of the NADPH oxidase 5 (NOX5)". J. Biol. Chem. 279 (18): 18583–91. doi:10.1074/jbc.M310268200. PMID 14982937.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jana A, Pahan K (2005). "Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons through redox-regulated activation of neutral sphingomyelinase". J. Neurosci. 24 (43): 9531–40. doi:10.1523/JNEUROSCI.3085-04.2004. PMID 15509740.
• Kawahara T, Ritsick D, Cheng G, Lambeth JD (2005). "Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1- and Nox2-dependent reactive oxygen generation". J. Biol. Chem. 280 (36): 31859–69. doi:10.1074/jbc.M501882200. PMID 15994299.CS1 maint: Multiple names: authors list (link)
• Femling JK, Nauseef WM, Weiss JP (2005). "Synergy between extracellular group IIA phospholipase A2 and phagocyte NADPH oxidase in digestion of phospholipids of Staphylococcus aureus ingested by human neutrophils". J. Immunol. 175 (7): 4653–61. PMID 16177112.CS1 maint: Multiple names: authors list (link)
• Cucoranu I, Clempus R, Dikalova A; et al. (2005). "NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts". Circ. Res. 97 (9): 900–7. doi:10.1161/01.RES.0000187457.24338.3D. PMID 16179589.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kamiguti AS, Serrander L, Lin K; et al. (2006). "Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia". J. Immunol. 175 (12): 8424–30. PMID 16339585.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fu X, Beer DG, Behar J; et al. (2006). "cAMP-response element-binding protein mediates acid-induced NADPH oxidase NOX5-S expression in Barrett esophageal adenocarcinoma cells". J. Biol. Chem. 281 (29): 20368–82. doi:10.1074/jbc.M603353200. PMID 16707484.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Duerrschmidt N, Stielow C, Muller G; et al. (2006). "NO-mediated regulation of NAD(P)H oxidase by laminar shear stress in human endothelial cells". J. Physiol. (Lond.). 576 (Pt 2): 557–67. doi:10.1113/jphysiol.2006.111070. PMID 16873416.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chenevier-Gobeaux C, Lemarechal H, Bonnefont-Rousselot D; et al. (2007). "Superoxide production and NADPH oxidase expression in human rheumatoid synovial cells: regulation by interleukin-1beta and tumour necrosis factor-alpha". Inflamm. Res. 55 (11): 483–90. doi:10.1007/s00011-006-6036-8. PMID 17122966.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jagnandan D, Church JE, Banfi B; et al. (2007). "Novel mechanism of activation of NADPH oxidase 5. calcium sensitization via phosphorylation". J. Biol. Chem. 282 (9): 6494–507. doi:10.1074/jbc.M608966200. PMID 17164239.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• BelAiba RS, Djordjevic T, Petry A; et al. (2007). "NOX5 variants are functionally active in endothelial cells". Free Radic. Biol. Med. 42 (4): 446–59. doi:10.1016/j.freeradbiomed.2006.10.054. PMID 17275676.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tirone F, Cox JA (2007). "NADPH oxidase 5 (NOX5) interacts with and is regulated by calmodulin". FEBS Lett. 581 (6): 1202–8. doi:10.1016/j.febslet.2007.02.047. PMID 17346712.
• Qin F, Simeone M, Patel R (2007). "Inhibition of NADPH oxidase reduces myocardial oxidative stress and apoptosis and improves cardiac function in heart failure after myocardial infarction". Free Radic. Biol. Med. 43 (2): 271–81. doi:10.1016/j.freeradbiomed.2007.04.021. PMID 17603936.CS1 maint: Multiple names: authors list (link)