MNAT1

Menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)
File:PBB Protein MNAT1 image.jpg PDB rendering based on 1g25.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1g25​
Identifiers
Symbols	MNAT1 ; MAT1; RNF66
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1821
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MNAT1 203565 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis), also known as MNAT1, is a human gene.

Cyclin-dependent kinases (CDKs), which play an essential role in cell cycle control of eukaryotic cells, are phosphorylated and thus activated by the CDK-activating kinase (CAK). CAK is a multisubunit protein that includes CDK7 (MIM 601955), cyclin H (CCNH; MIM 601953), and MAT1. MAT1 (for 'menage a trois-1') is involved in the assembly of the CAK complex.[supplied by OMIM]

Further reading

• Jeang KT (1998). "Tat, Tat-associated kinase, and transcription". J. Biomed. Sci. 5 (1): 24–7. PMID 9570510.
• Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation". Curr. Biol. 8 (13): R447–9. PMID 9651670.
• Le Goff P, Montano MM, Schodin DJ, Katzenellenbogen BS (1994). "Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity". J. Biol. Chem. 269 (6): 4458–66. PMID 8308015.CS1 maint: Multiple names: authors list (link)
• Yee A, Nichols MA, Wu L; et al. (1996). "Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor". Cancer Res. 55 (24): 6058–62. PMID 8521393.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tassan JP, Jaquenoud M, Fry AM; et al. (1996). "In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein". EMBO J. 14 (22): 5608–17. PMID 8521818.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Blau J, Xiao H, McCracken S; et al. (1996). "Three functional classes of transcriptional activation domain". Mol. Cell. Biol. 16 (5): 2044–55. PMID 8628270.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Reardon JT, Ge H, Gibbs E; et al. (1996). "Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6482–7. PMID 8692841.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Drapkin R, Le Roy G, Cho H; et al. (1996). "Human cyclin-dependent kinase-activating kinase exists in three distinct complexes". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6488–93. PMID 8692842.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–10. PMID 8849451.
• Parada CA, Roeder RG (1996). "Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain". Nature. 384 (6607): 375–8. doi:10.1038/384375a0. PMID 8934526.
• García-Martínez LF, Ivanov D, Gaynor RB (1997). "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes". J. Biol. Chem. 272 (11): 6951–8. PMID 9054383.CS1 maint: Multiple names: authors list (link)
• Marinoni JC, Roy R, Vermeulen W; et al. (1997). "Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH". EMBO J. 16 (5): 1093–102. doi:10.1093/emboj/16.5.1093. PMID 9118947.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cujec TP, Cho H, Maldonado E; et al. (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme". Mol. Cell. Biol. 17 (4): 1817–23. PMID 9121429.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rossignol M, Kolb-Cheynel I, Egly JM (1997). "Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH". EMBO J. 16 (7): 1628–37. doi:10.1093/emboj/16.7.1628. PMID 9130708.CS1 maint: Multiple names: authors list (link)
• García-Martínez LF, Mavankal G, Neveu JM; et al. (1997). "Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription". EMBO J. 16 (10): 2836–50. doi:10.1093/emboj/16.10.2836. PMID 9184228.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nekhai S, Shukla RR, Kumar A (1997). "A human primary T-lymphocyte-derived human immunodeficiency virus type 1 Tat-associated kinase phosphorylates the C-terminal domain of RNA polymerase II and induces CAK activity". J. Virol. 71 (10): 7436–41. PMID 9311822.CS1 maint: Multiple names: authors list (link)
• Cujec TP, Okamoto H, Fujinaga K; et al. (1997). "The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II". Genes Dev. 11 (20): 2645–57. PMID 9334327.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Inamoto S, Segil N, Pan ZQ; et al. (1997). "The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors". J. Biol. Chem. 272 (47): 29852–8. PMID 9368058.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ko LJ, Shieh SY, Chen X; et al. (1997). "p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner". Mol. Cell. Biol. 17 (12): 7220–9. PMID 9372954.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Eki T, Okumura K, Abe M; et al. (1998). "Mapping of the human genes encoding cyclin H (CCNH) and the CDK-activating kinase (CAK) assembly factor MAT1 (MNAT1) to chromosome bands 5q13.3-q14 and 14q23, respectively". Genomics. 47 (1): 115–20. doi:10.1006/geno.1997.5053. PMID 9465303.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)