LYVE1

Extracellular link domain containing 1
Identifiers
Symbols	XLKD1 ; CRSBP-1; HAR; LYVE-1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4868
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE XLKD1 219059 s at tn.png
File:PBB GE XLKD1 220037 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Extracellular link domain containing 1, also known as XLKD1, is a human gene.

This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis.

Further reading

• Jackson DG (2003). "The lymphatics revisited: new perspectives from the hyaluronan receptor LYVE-1". Trends Cardiovasc. Med. 13 (1): 1–7. PMID 12554094.
• Banerji S, Ni J, Wang SX; et al. (1999). "LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan". J. Cell Biol. 144 (4): 789–801. PMID 10037799.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cunnick GH, Jiang WG, Gomez KF, Mansel RE (2001). "Lymphangiogenesis quantification using quantitative PCR and breast cancer as a model". Biochem. Biophys. Res. Commun. 288 (4): 1043–6. doi:10.1006/bbrc.2001.5869. PMID 11689016.CS1 maint: Multiple names: authors list (link)
• Mouta Carreira C, Nasser SM, di Tomaso E; et al. (2001). "LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis". Cancer Res. 61 (22): 8079–84. PMID 11719431.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cursiefen C, Schlötzer-Schrehardt U, Küchle M; et al. (2002). "Lymphatic vessels in vascularized human corneas: immunohistochemical investigation using LYVE-1 and podoplanin". Invest. Ophthalmol. Vis. Sci. 43 (7): 2127–35. PMID 12091407.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Huang SS, Tang FM, Huang YH; et al. (2003). "Cloning, expression, characterization, and role in autocrine cell growth of cell surface retention sequence binding protein-1". J. Biol. Chem. 278 (44): 43855–69. doi:10.1074/jbc.M306411200. PMID 12912978.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Otsuki T, Ota T, Nishikawa T; et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu T, Qian WJ, Gritsenko MA; et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nguyen VA, Kutzner H, Fürhapter C; et al. (2006). "Infantile hemangioma is a proliferation of LYVE-1-negative blood endothelial cells without lymphatic competence". Mod. Pathol. 19 (2): 291–8. doi:10.1038/modpathol.3800537. PMID 16424896.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gu B, Alexander JS, Gu Y; et al. (2007). "Expression of lymphatic vascular endothelial hyaluronan receptor-1 (LYVE-1) in the human placenta". Lymphatic research and biology. 4 (1): 11–7. doi:10.1089/lrb.2006.4.11. PMID 16569201.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Llovet JM, Chen Y, Wurmbach E; et al. (2007). "A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis". Gastroenterology. 131 (6): 1758–67. doi:10.1053/j.gastro.2006.09.014. PMID 17087938.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)