KATNB1
| Katanin p80 (WD repeat containing) subunit B 1 | |||||||||||
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| Symbols | KATNB1 ; KAT | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 4302 | ||||||||||
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| Species | Human | Mouse | |||||||||
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Katanin p80 (WD repeat containing) subunit B 1, also known as KATNB1, is a human gene.[1]
Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases.[1]
References
Further reading
- Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Toyo-Oka K, Sasaki S, Yano Y; et al. (2006). "Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration". Hum. Mol. Genet. 14 (21): 3113–28. doi:10.1093/hmg/ddi339. PMID 16203747.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Karabay A, Yu W, Solowska JM; et al. (2004). "Axonal growth is sensitive to the levels of katanin, a protein that severs microtubules". J. Neurosci. 24 (25): 5778–88. doi:10.1523/JNEUROSCI.1382-04.2004. PMID 15215300.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- McNally KP, Bazirgan OA, McNally FJ (2000). "Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin". J. Cell. Sci. 113 ( Pt 9): 1623–33. PMID 10751153.
- Ahmad FJ, Yu W, McNally FJ, Baas PW (1999). "An essential role for katanin in severing microtubules in the neuron". J. Cell Biol. 145 (2): 305–15. PMID 10209026.
- McNally FJ, Thomas S (1999). "Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs". Mol. Biol. Cell. 9 (7): 1847–61. PMID 9658175.
- Hartman JJ, Mahr J, McNally K; et al. (1998). "Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit". Cell. 93 (2): 277–87. PMID 9568719.
- McNally FJ, Okawa K, Iwamatsu A, Vale RD (1997). "Katanin, the microtubule-severing ATPase, is concentrated at centrosomes". J. Cell. Sci. 109 ( Pt 3): 561–7. PMID 8907702.
- McNally FJ, Vale RD (1993). "Identification of katanin, an ATPase that severs and disassembles stable microtubules". Cell. 75 (3): 419–29. PMID 8221885.
- Cowan NJ, Dobner PR, Fuchs EV, Cleveland DW (1984). "Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions". Mol. Cell. Biol. 3 (10): 1738–45. PMID 6646120.
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