Integrin-linked kinase

Integrin-linked kinase
Identifiers
Symbols	ILK ; DKFZp686F1765; P59
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3318
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Integrin-linked kinase (ILK) is a 59kDa protein originally identified while conducting a yeast-two hybrid screen with integrin β1 as the bait protein (Hannigan et al., 1996). Since its discovery, ILK has been associated with multiple cellular functions including cell migration, cell proliferation, cell-adhesions, signal transduction

Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.

In 2008, ILK was found to localize to the centrosome and regulate mitotic spindle organization.

Further reading

• Dedhar S (2000). "Cell-substrate interactions and signaling through ILK". Curr. Opin. Cell Biol. 12 (2): 250–6. PMID 10712922.
• Persad S, Dedhar S (2004). "The role of integrin-linked kinase (ILK) in cancer progression". Cancer Metastasis Rev. 22 (4): 375–84. PMID 12884912.
• Srivastava D, Yu S (2006). "Stretching to meet needs: integrin-linked kinase and the cardiac pump". Genes Dev. 20 (17): 2327–31. doi:10.1101/gad.1472506. PMID 16951248.
• Hannigan GE, Leung-Hagesteijn C, Fitz-Gibbon L; et al. (1996). "Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase". Nature. 379 (6560): 91–6. doi:10.1038/379091a0. PMID 8538749.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hannigan GE, Bayani J, Weksberg R; et al. (1997). "Mapping of the gene encoding the integrin-linked kinase, ILK, to human chromosome 11p15.5-p15.4". Genomics. 42 (1): 177–9. doi:10.1006/geno.1997.4719. PMID 9177792.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li F, Liu J, Mayne R, Wu C (1997). "Identification and characterization of a mouse protein kinase that is highly homologous to human integrin-linked kinase". Biochim. Biophys. Acta. 1358 (3): 215–20. PMID 9366252.CS1 maint: Multiple names: authors list (link)
• Delcommenne M, Tan C, Gray V; et al. (1998). "Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11211–6. PMID 9736715.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chung DH, Lee JI, Kook MC; et al. (1998). "ILK (beta1-integrin-linked protein kinase): a novel immunohistochemical marker for Ewing's sarcoma and primitive neuroectodermal tumour". Virchows Arch. 433 (2): 113–7. PMID 9737788.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tu Y, Li F, Goicoechea S, Wu C (1999). "The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells". Mol. Cell. Biol. 19 (3): 2425–34. PMID 10022929.CS1 maint: Multiple names: authors list (link)
• Feng J, Ito M, Ichikawa K; et al. (2000). "Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase". J. Biol. Chem. 274 (52): 37385–90. PMID 10601309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Janji B, Melchior C, Vallar L, Kieffer N (2000). "Cloning of an isoform of integrin-linked kinase (ILK) that is upregulated in HT-144 melanoma cells following TGF-beta1 stimulation". Oncogene. 19 (27): 3069–77. doi:10.1038/sj.onc.1203640. PMID 10871859.CS1 maint: Multiple names: authors list (link)
• Velyvis A, Yang Y, Wu C, Qin J (2001). "Solution structure of the focal adhesion adaptor PINCH LIM1 domain and characterization of its interaction with the integrin-linked kinase ankyrin repeat domain". J. Biol. Chem. 276 (7): 4932–9. doi:10.1074/jbc.M007632200. PMID 11078733.CS1 maint: Multiple names: authors list (link)
• Matsumoto M, Ogawa W, Hino Y; et al. (2001). "Inhibition of insulin-induced activation of Akt by a kinase-deficient mutant of the epsilon isozyme of protein kinase C.". J. Biol. Chem. 276 (17): 14400–6. doi:10.1074/jbc.M011093200. PMID 11278835.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nikolopoulos SN, Turner CE (2001). "Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions". J. Biol. Chem. 276 (26): 23499–505. doi:10.1074/jbc.M102163200. PMID 11304546.
• Persad S, Attwell S, Gray V; et al. (2001). "Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343". J. Biol. Chem. 276 (29): 27462–9. doi:10.1074/jbc.M102940200. PMID 11313365.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tu Y, Huang Y, Zhang Y; et al. (2001). "A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading". J. Cell Biol. 153 (3): 585–98. PMID 11331308.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Leung-Hagesteijn C, Mahendra A, Naruszewicz I, Hannigan GE (2001). "Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1". EMBO J. 20 (9): 2160–70. doi:10.1093/emboj/20.9.2160. PMID 11331582.CS1 maint: Multiple names: authors list (link)
• Yamaji S, Suzuki A, Sugiyama Y; et al. (2001). "A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction". J. Cell Biol. 153 (6): 1251–64. PMID 11402068.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen R, Kim O, Yang J; et al. (2001). "Regulation of Akt/PKB activation by tyrosine phosphorylation". J. Biol. Chem. 276 (34): 31858–62. doi:10.1074/jbc.C100271200. PMID 11445557.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fielding A, Dobreva I, McDonald PC; et al. (2008). "Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization". J. Cell Biol. 180 (4): 681–9. doi:10.1083/jcb.200710074. PMID 18283114.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)