GAPDHS

Glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
Identifiers
Symbols	GAPDHS ; GAPD2; GAPDH-2; GAPDS; HSD-35
External IDs	Template:OMIM5 Template:MGI HomoloGene: 56402
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Glyceraldehyde-3-phosphate dehydrogenase, spermatogenic, also known as GAPDHS, is a human gene.

This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility.

Further reading

• Cooper TG, Yeung CH (2001). "Approaches to post-testicular contraception". Asian J. Androl. 1 (1–2): 29–36. PMID 11225901.
• Benham FJ, Povey S (1989). "Members of the human glyceraldehyde-3-phosphate dehydrogenase-related gene family map to dispersed chromosomal locations". Genomics. 5 (2): 209–14. PMID 2793178.
• Peterson RN, Freund M (1973). "Effects of (H + ), (Na + ), (K + ) and certain membrane-active drugs on glycolysis, motility, and ATP synthesis by human spermatozoa". Biol. Reprod. 8 (3): 350–7. PMID 4349855.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Westhoff D, Kamp G (1997). "Glyceraldehyde 3-phosphate dehydrogenase is bound to the fibrous sheath of mammalian spermatozoa". J. Cell. Sci. 110 ( Pt 15): 1821–9. PMID 9264469.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Goodwin LO, Karabinus DS, Pergolizzi RG, Benoff S (2000). "L-type voltage-dependent calcium channel alpha-1C subunit mRNA is present in ejaculated human spermatozoa". Mol. Hum. Reprod. 6 (2): 127–36. PMID 10655454.CS1 maint: Multiple names: authors list (link)
• Welch JE, Brown PL, O'Brien DA; et al. (2000). "Human glyceraldehyde 3-phosphate dehydrogenase-2 gene is expressed specifically in spermatogenic cells". J. Androl. 21 (2): 328–38. PMID 10714828.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bone W, Jones AR, Morin C; et al. (2001). "Susceptibility of glycolytic enzyme activity and motility of spermatozoa from rat, mouse, and human to inhibition by proven and putative chlorinated antifertility compounds in vitro". J. Androl. 22 (3): 464–70. PMID 11330647.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grimwood J, Gordon LA, Olsen A; et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yamashita R, Shirota M; et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li Y, Nowotny P, Holmans P; et al. (2004). "Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15688–93. doi:10.1073/pnas.0403535101. PMID 15507493.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kodama R, Kondo T, Yokote H; et al. (2006). "Nuclear localization of glyceraldehyde-3-phosphate dehydrogenase is not involved in the initiation of apoptosis induced by 1-Methyl-4-phenyl-pyridium iodide (MPP+)". Genes Cells. 10 (12): 1211–9. doi:10.1111/j.1365-2443.2005.00911.x. PMID 16324157.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Welch JE, Barbee RR, Magyar PL; et al. (2007). "Expression of the spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase (GAPDS) in rat testis". Mol. Reprod. Dev. 73 (8): 1052–60. doi:10.1002/mrd.20235. PMID 16700075.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yatsenko AN, Roy A, Chen R; et al. (2007). "Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization". Hum. Mol. Genet. 15 (23): 3411–9. doi:10.1093/hmg/ddl417. PMID 17047026.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)