DLL4

Delta-like 4 (Drosophila)
Identifiers
Symbols	DLL4 ; MGC126344; hdelta2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 10411
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Delta-like 4 (Drosophila), also known as DLL4, is a human gene.

This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.

Further reading

• Shutter JR, Scully S, Fan W; et al. (2000). "Dll4, a novel Notch ligand expressed in arterial endothelium". Genes Dev. 14 (11): 1313–8. PMID 10837024.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yoneya T, Tahara T, Nagao K; et al. (2001). "Molecular cloning of delta-4, a new mouse and human Notch ligand". J. Biochem. 129 (1): 27–34. PMID 11134954.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yan XQ, Sarmiento U, Sun Y; et al. (2002). "A novel Notch ligand, Dll4, induces T-cell leukemia/lymphoma when overexpressed in mice by retroviral-mediated gene transfer". Blood. 98 (13): 3793–9. PMID 11739188.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mailhos C, Modlich U, Lewis J; et al. (2002). "Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis". Differentiation. 69 (2–3): 135–44. PMID 11798067.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dorsch M, Zheng G, Yowe D; et al. (2002). "Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease". Blood. 100 (6): 2046–55. PMID 12200365.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu ZJ, Shirakawa T, Li Y; et al. (2003). "Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis". Mol. Cell. Biol. 23 (1): 14–25. PMID 12482957.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tohda S, Murata-Ohsawa M, Sakano S, Nara N (2003). "Notch ligands, Delta-1 and Delta-4 suppress the self-renewal capacity and long-term growth of two myeloblastic leukemia cell lines". Int. J. Oncol. 22 (5): 1073–9. PMID 12684674.CS1 maint: Multiple names: authors list (link)
• Shawber CJ, Das I, Francisco E, Kitajewski J (2003). "Notch signaling in primary endothelial cells". Ann. N. Y. Acad. Sci. 995: 162–70. PMID 12814948.CS1 maint: Multiple names: authors list (link)
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lauret E, Catelain C, Titeux M; et al. (2004). "Membrane-bound delta-4 notch ligand reduces the proliferative activity of primitive human hematopoietic CD34+CD38low cells while maintaining their LTC-IC potential". Leukemia. 18 (4): 788–97. doi:10.1038/sj.leu.2403288. PMID 14990974.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McKeane DP, Meyer J, Dobrin SE; et al. (2005). "No causative DLL4 mutations in periodic catatonia patients from 15q15 linked families". Schizophrenia Research. 75 (1): 1–3. doi:10.1016/j.schres.2004.07.017. PMID 15820317.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Patel NS, Li JL, Generali D; et al. (2005). "Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function". Cancer Res. 65 (19): 8690–7. doi:10.1158/0008-5472.CAN-05-1208. PMID 16204037.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Patel NS, Dobbie MS, Rochester M; et al. (2006). "Up-regulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer". Clin. Cancer Res. 12 (16): 4836–44. doi:10.1158/1078-0432.CCR-06-0285. PMID 16914569.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lefort N, Benne C, Lelièvre JD; et al. (2007). "Short exposure to Notch ligand Delta-4 is sufficient to induce T-cell differentiation program and to increase the T cell potential of primary human CD34+ cells". Exp. Hematol. 34 (12): 1720–9. doi:10.1016/j.exphem.2006.08.007. PMID 17157169.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fung E, Tang SM, Canner JP; et al. (2007). "Delta-like 4 induces notch signaling in macrophages: implications for inflammation". Circulation. 115 (23): 2948–56. doi:10.1161/CIRCULATIONAHA.106.675462. PMID 17533181.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hodkinson PS, Elliott PA, Lad Y; et al. (2007). "Mammalian NOTCH-1 activates beta1 integrins via the small GTPase R-Ras". J. Biol. Chem. 282 (39): 28991–9001. doi:10.1074/jbc.M703601200. PMID 17664272.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zang S, Ji Ch, Qu X; et al. (2007). "A study on Notch signaling in human breast cancer". Neoplasma. 54 (4): 304–10. PMID 17822320.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)