Cyclin E1

Cyclin E1
PDB rendering based on 1w98.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1w98​
Identifiers
Symbols	CCNE1 ; CCNE
External IDs	Template:OMIM5 Template:MGI HomoloGene: 14452
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Cyclin E1, also known as CCNE1, is a human gene.

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.

See also

• cyclin E

Further reading

• Akita H (2003). "[Prognostic importance of altered expression of cell cycle regulators in lung cancer]". Nippon Rinsho. 60 Suppl 5: 267–71. PMID 12101670.
• Mazumder S, DuPree EL, Almasan A (2004). "A dual role of cyclin E in cell proliferation and apoptosis may provide a target for cancer therapy". Current cancer drug targets. 4 (1): 65–75. PMID 14965268.CS1 maint: Multiple names: authors list (link)
• Hinds PW, Mittnacht S, Dulic V; et al. (1992). "Regulation of retinoblastoma protein functions by ectopic expression of human cyclins". Cell. 70 (6): 993–1006. PMID 1388095.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Koff A, Giordano A, Desai D; et al. (1992). "Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle". Science. 257 (5077): 1689–94. PMID 1388288.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lew DJ, Dulić V, Reed SI (1991). "Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast". Cell. 66 (6): 1197–206. PMID 1833066.CS1 maint: Multiple names: authors list (link)
• Koff A, Cross F, Fisher A; et al. (1991). "Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family". Cell. 66 (6): 1217–28. PMID 1833068.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Demetrick DJ, Matsumoto S, Hannon GJ; et al. (1995). "Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3)". Cytogenet. Cell Genet. 69 (3–4): 190–2. PMID 7698009.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohtsubo M, Theodoras AM, Schumacher J; et al. (1995). "Human cyclin E, a nuclear protein essential for the G1-to-S phase transition". Mol. Cell. Biol. 15 (5): 2612–24. PMID 7739542.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sewing A, Rönicke V, Bürger C; et al. (1994). "Alternative splicing of human cyclin E.". J. Cell. Sci. 107 ( Pt 2): 581–8. PMID 8207080.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dyson N, Dembski M, Fattaey A; et al. (1993). "Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1". J. Virol. 67 (12): 7641–7. PMID 8230483.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li Y, Graham C, Lacy S; et al. (1994). "The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E.". Genes Dev. 7 (12A): 2366–77. PMID 8253383.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu X, Burke SP (1996). "Roles of active site residues and the NH2-terminal domain in the catalysis and substrate binding of human Cdc25". J. Biol. Chem. 271 (9): 5118–24. PMID 8617791.
• Ohtani K, DeGregori J, Nevins JR (1996). "Regulation of the cyclin E gene by transcription factor E2F1". Proc. Natl. Acad. Sci. U.S.A. 92 (26): 12146–50. PMID 8618861.CS1 maint: Multiple names: authors list (link)
• Geng Y, Eaton EN, Picón M; et al. (1996). "Regulation of cyclin E transcription by E2Fs and retinoblastoma protein". Oncogene. 12 (6): 1173–80. PMID 8649818.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Poon RY, Jiang W, Toyoshima H, Hunter T (1996). "Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage". J. Biol. Chem. 271 (22): 13283–91. PMID 8662825.CS1 maint: Multiple names: authors list (link)
• Chen J, Saha P, Kornbluth S; et al. (1996). "Cyclin-binding motifs are essential for the function of p21CIP1". Mol. Cell. Biol. 16 (9): 4673–82. PMID 8756624.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li H, Lahti JM, Valentine M; et al. (1997). "Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors". Genomics. 32 (2): 253–9. doi:10.1006/geno.1996.0112. PMID 8833152.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Won KA, Reed SI (1996). "Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E.". EMBO J. 15 (16): 4182–93. PMID 8861947.
• Sala A, Kundu M, Casella I; et al. (1997). "Activation of human B-MYB by cyclins". Proc. Natl. Acad. Sci. U.S.A. 94 (2): 532–6. PMID 9012818.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mumberg D, Wick M, Bürger C; et al. (1997). "Cyclin ET, a new splice variant of human cyclin E with a unique expression pattern during cell cycle progression and differentiation". Nucleic Acids Res. 25 (11): 2098–105. PMID 9153308.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)