CIB1

Calcium and integrin binding 1 (calmyrin)
PDB rendering based on 1dgu.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1dgu​, 1dgv​, 1xo5​, 1y1a​
Identifiers
Symbols	CIB1 ; CALMYRIN; CIB; KIP; SIP2-28
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4654
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Calcium and integrin binding 1 (calmyrin), also known as CIB1, is a human gene.

The protein encoded by this gene is a member of the calcium-binding protein family. The specific function of this protein has not yet been determined; however this protein is known to interact with DNA-dependent protein kinase and may play a role in kinase-phosphatase regulation of DNA end joining. This protein also interacts with integrin alpha(IIb)beta(3), which may implicate this protein as a regulatory molecule for alpha(IIb)beta(3).

Further reading

• Naik UP, Patel PM, Parise LV (1997). "Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain". J. Biol. Chem. 272 (8): 4651–4. PMID 9030514.CS1 maint: Multiple names: authors list (link)
• Wu X, Lieber MR (1997). "Interaction between DNA-dependent protein kinase and a novel protein, KIP". Mutat. Res. 385 (1): 13–20. PMID 9372844.
• Seki N, Hayashi A, Abe M; et al. (1999). "Chromosomal assignment of the gene for human DNA-PKcs interacting protein (KIP) on chromosome 15q25.3-q26.1 by somatic hybrid analysis and fluorescence in situ hybridization". J. Hum. Genet. 43 (4): 275–7. PMID 9852683.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stabler SM, Ostrowski LL, Janicki SM, Monteiro MJ (1999). "A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein". J. Cell Biol. 145 (6): 1277–92. PMID 10366599.CS1 maint: Multiple names: authors list (link)
• Kauselmann G, Weiler M, Wulff P; et al. (1999). "The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity". EMBO J. 18 (20): 5528–39. doi:10.1093/emboj/18.20.5528. PMID 10523297.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hwang PM, Vogel HJ (2000). "Structures of the platelet calcium- and integrin-binding protein and the alphaIIb-integrin cytoplasmic domain suggest a mechanism for calcium-regulated recognition; homology modelling and NMR studies". J. Mol. Recognit. 13 (2): 83–92. doi:10.1002/(SICI)1099-1352(200003/04)13:2<83::AID-JMR491>3.0.CO;2-A. PMID 10822252.
• Hattori A, Seki N, Hayashi A; et al. (2000). "Genomic structure of mouse and human genes for DNA-PKcs interacting protein (KIP)". DNA Seq. 10 (6): 415–8. PMID 10826701.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Holtrich U, Wolf G, Yuan J; et al. (2000). "Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages". Oncogene. 19 (42): 4832–9. doi:10.1038/sj.onc.1203845. PMID 11039900.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Haataja L, Kaartinen V, Groffen J, Heisterkamp N (2002). "The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading". J. Biol. Chem. 277 (10): 8321–8. doi:10.1074/jbc.M105363200. PMID 11756406.CS1 maint: Multiple names: authors list (link)
• Whitehouse C, Chambers J, Howe K; et al. (2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube". Eur. J. Biochem. 269 (2): 538–45. PMID 11856312.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hollenbach AD, McPherson CJ, Lagutina I, Grosveld G (2002). "The EF-hand calcium-binding protein calmyrin inhibits the transcriptional and DNA-binding activity of Pax3". Biochim. Biophys. Acta. 1574 (3): 321–8. PMID 11997098.CS1 maint: Multiple names: authors list (link)
• Henderson MJ, Russell AJ, Hird S; et al. (2002). "EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response". J. Biol. Chem. 277 (29): 26468–78. doi:10.1074/jbc.M203527200. PMID 12011095.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Barry WT, Boudignon-Proudhon C, Shock DD; et al. (2002). "Molecular basis of CIB binding to the integrin alpha IIb cytoplasmic domain". J. Biol. Chem. 277 (32): 28877–83. doi:10.1074/jbc.M202983200. PMID 12023286.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ma S, Liu MA, Yuan YL, Erikson RL (2003). "The serum-inducible protein kinase Snk is a G1 phase polo-like kinase that is inhibited by the calcium- and integrin-binding protein CIB". Mol. Cancer Res. 1 (5): 376–84. PMID 12651910.CS1 maint: Multiple names: authors list (link)
• Naik UP, Naik MU (2003). "Association of CIB with GPIIb/IIIa during outside-in signaling is required for platelet spreading on fibrinogen". Blood. 102 (4): 1355–62. doi:10.1182/blood-2003-02-0591. PMID 12714504.
• Naik MU, Naik UP (2004). "Calcium-and integrin-binding protein regulates focal adhesion kinase activity during platelet spreading on immobilized fibrinogen". Blood. 102 (10): 3629–36. doi:10.1182/blood-2003-05-1703. PMID 12881299.
• Yamniuk AP, Nguyen LT, Hoang TT, Vogel HJ (2004). "Metal ion binding properties and conformational states of calcium- and integrin-binding protein". Biochemistry. 43 (9): 2558–68. doi:10.1021/bi035432b. PMID 14992593.CS1 maint: Multiple names: authors list (link)
• Lee GE, Yu EY, Cho CH; et al. (2004). "DNA-protein kinase catalytic subunit-interacting protein KIP binds telomerase by interacting with human telomerase reverse transcriptase". J. Biol. Chem. 279 (33): 34750–5. doi:10.1074/jbc.M401843200. PMID 15190070.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.