CDK2AP1

CDK2-associated protein 1
Identifiers
Symbols	CDK2AP1 ; DOC1; DORC1; ST19; doc-1; p12DOC-1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3411
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

CDK2-associated protein 1, also known as CDK2AP1, is a human gene.

The protein encoded by this gene is a specific CDK2-associated protein, which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggested the regulatory role in DNA replication during S phase of the cell cycle. A similar gene in hamster was isolated from, and functions as a growth suppressor of normal keratinocytes.

Further reading

• Daigo Y, Suzuki K, Maruyama O; et al. (1997). "Isolation, mapping and mutation analysis of a human cDNA homologous to the doc-1 gene of the Chinese hamster, a candidate tumor suppressor for oral cancer". Genes Chromosomes Cancer. 20 (2): 204–7. PMID 9331572.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tsuji T, Duh FM, Latif F; et al. (1998). "Cloning, mapping, expression, function, and mutation analyses of the human ortholog of the hamster putative tumor suppressor gene Doc-1". J. Biol. Chem. 273 (12): 6704–9. PMID 9506968.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Matsuo K, Shintani S, Tsuji T; et al. (2000). "p12(DOC-1), a growth suppressor, associates with DNA polymerase alpha/primase". FASEB J. 14 (10): 1318–24. PMID 10877824.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shintani S, Ohyama H, Zhang X; et al. (2000). "p12(DOC-1) is a novel cyclin-dependent kinase 2-associated protein". Mol. Cell. Biol. 20 (17): 6300–7. PMID 10938106.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yuan Z, Sotsky Kent T, Weber TK (2003). "Differential expression of DOC-1 in microsatellite-unstable human colorectal cancer". Oncogene. 22 (40): 6304–10. doi:10.1038/sj.onc.1206609. PMID 13679870.CS1 maint: Multiple names: authors list (link)
• Hu MG, Hu GF, Kim Y; et al. (2004). "Role of p12(CDK2-AP1) in transforming growth factor-beta1-mediated growth suppression". Cancer Res. 64 (2): 490–9. PMID 14744761.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Buajeeb W, Zhang X, Ohyama H; et al. (2004). "Interaction of the CDK2-associated protein-1, p12(DOC-1/CDK2AP1), with its homolog, p14(DOC-1R)". Biochem. Biophys. Res. Commun. 315 (4): 998–1003. doi:10.1016/j.bbrc.2004.02.003. PMID 14985111.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim Y, Ohyama H, Patel V; et al. (2005). "Mutation of Cys105 inhibits dimerization of p12CDK2-AP1 and its growth suppressor effect". J. Biol. Chem. 280 (24): 23273–9. doi:10.1074/jbc.M412929200. PMID 15840587.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Peng H, Shintani S, Kim Y, Wong DT (2007). "Loss of p12CDK2-AP1 expression in human oral squamous cell carcinoma with disrupted transforming growth factor-beta-Smad signaling pathway". Neoplasia. 8 (12): 1028–36. doi:10.1593/neo.06580. PMID 17217620.CS1 maint: Multiple names: authors list (link)
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shin J, Yuan Z, Fordyce K; et al. (2007). "A del T poly T (8) mutation in the 3' untranslated region (UTR) of the CDK2-AP1 gene is functionally significant causing decreased mRNA stability resulting in decreased CDK2-AP1 expression in human microsatellite unstable (MSI) colorectal cancer (CRC)". Surgery. 142 (2): 222–7. doi:10.1016/j.surg.2007.04.002. PMID 17689689.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)