ADARB1

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Adenosine deaminase, RNA-specific, B1 (RED1 homolog rat)
PDB rendering based on 1zy7.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols ADARB1 ; ADAR2; ADAR2a; ADAR2a-L1; ADAR2a-L2; ADAR2a-L3; ADAR2b; ADAR2d; ADAR2g; DRABA2; DRADA2; RED1
External IDs Template:OMIM5 Template:MGI HomoloGene: 8280
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Adenosine deaminase, RNA-specific, B1 (RED1 homolog rat), also known as ADARB1, is a human gene.[1]

This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: ADARB1 adenosine deaminase, RNA-specific, B1 (RED1 homolog rat)".

Further reading

  • Valenzuela A, Blanco J, Callebaut C; et al. (1997). "HIV-1 envelope gp120 and viral particles block adenosine deaminase binding to human CD26". Adv. Exp. Med. Biol. 421: 185–92. PMID 9330696.
  • Keegan LP, Leroy A, Sproul D, O'Connell MA (2005). "Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes". Genome Biol. 5 (2): 209. doi:10.1186/gb-2004-5-2-209. PMID 14759252.
  • Melcher T, Maas S, Herb A; et al. (1996). "A mammalian RNA editing enzyme". Nature. 379 (6564): 460–4. doi:10.1038/379460a0. PMID 8559253.
  • O'Connell MA, Gerber A, Keller W (1997). "Purification of human double-stranded RNA-specific editase 1 (hRED1) involved in editing of brain glutamate receptor B pre-mRNA". J. Biol. Chem. 272 (1): 473–8. PMID 8995285.
  • Valenzuela A, Blanco J, Callebaut C; et al. (1997). "Adenosine deaminase binding to human CD26 is inhibited by HIV-1 envelope glycoprotein gp120 and viral particles". J. Immunol. 158 (8): 3721–9. PMID 9103436.
  • Lai F, Chen CX, Carter KC, Nishikura K (1997). "Editing of glutamate receptor B subunit ion channel RNAs by four alternatively spliced DRADA2 double-stranded RNA adenosine deaminases". Mol. Cell. Biol. 17 (5): 2413–24. PMID 9111310.
  • Yang JH, Sklar P, Axel R, Maniatis T (1997). "Purification and characterization of a human RNA adenosine deaminase for glutamate receptor B pre-mRNA editing". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4354–9. PMID 9113993.
  • Mittaz L, Scott HS, Rossier C; et al. (1997). "Cloning of a human RNA editing deaminase (ADARB1) of glutamate receptors that maps to chromosome 21q22.3". Genomics. 41 (2): 210–7. doi:10.1006/geno.1997.4655. PMID 9143496.
  • Gerber A, O'Connell MA, Keller W (1997). "Two forms of human double-stranded RNA-specific editase 1 (hRED1) generated by the insertion of an Alu cassette". RNA. 3 (5): 453–63. PMID 9149227.
  • Villard L, Tassone F, Haymowicz M; et al. (1997). "Map location, genomic organization and expression patterns of the human RED1 RNA editase". Somat. Cell Mol. Genet. 23 (2): 135–45. PMID 9330641.
  • Hattori M, Fujiyama A, Taylor TD; et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
  • Blanco J, Valenzuela A, Herrera C; et al. (2000). "The HIV-1 gp120 inhibits the binding of adenosine deaminase to CD26 by a mechanism modulated by CD4 and CXCR4 expression". FEBS Lett. 477 (1–2): 123–8. PMID 10899322.
  • Herrera C, Morimoto C, Blanco J; et al. (2001). "Comodulation of CXCR4 and CD26 in human lymphocytes". J. Biol. Chem. 276 (22): 19532–9. doi:10.1074/jbc.M004586200. PMID 11278278.
  • Maas S, Patt S, Schrey M, Rich A (2002). "Underediting of glutamate receptor GluR-B mRNA in malignant gliomas". Proc. Natl. Acad. Sci. U.S.A. 98 (25): 14687–92. doi:10.1073/pnas.251531398. PMID 11717408.
  • Jayan GC, Casey JL (2002). "Increased RNA editing and inhibition of hepatitis delta virus replication by high-level expression of ADAR1 and ADAR2". J. Virol. 76 (8): 3819–27. PMID 11907222.
  • Jaikaran DC, Collins CH, MacMillan AM (2002). "Adenosine to inosine editing by ADAR2 requires formation of a ternary complex on the GluR-B R/G site". J. Biol. Chem. 277 (40): 37624–9. doi:10.1074/jbc.M204126200. PMID 12163487.
  • Jayan GC, Casey JL (2002). "Inhibition of hepatitis delta virus RNA editing by short inhibitory RNA-mediated knockdown of ADAR1 but not ADAR2 expression". J. Virol. 76 (23): 12399–404. PMID 12414985.
  • Slavov D, Gardiner K (2003). "Phylogenetic comparison of the pre-mRNA adenosine deaminase ADAR2 genes and transcripts: conservation and diversity in editing site sequence and alternative splicing patterns". Gene. 299 (1–2): 83–94. PMID 12459255.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.

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