Singh-Williams-McAlister syndrome

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Talo-patello-scaphoid osteolysis

Overview

Singh-Williams-McAlister syndrome[1] is a rare syndrome characterized by the resorption of bones (ankles, knees and wrists). Singh-Williams-McAlister syndrome is a syndrome belonging to the category of carpal-tarsal osteolysis diseases without nephropathy.

Pathophysiology

It is characterised by bilateral osteolysis of the tali, scaphoids, patella and short fourth metacarpals.

Genetics

Autosomal recessive inheritance is suspected.

Epidemiology and Demographics

Prevalance: <1 / 1 000 000

Diagnosis

Symptoms

The osteolysis is accompanied by periarticular swelling and pain.

Treatment

Supportive care of chronic pain is required.

References

  1. "Orphanet: Talo patello scaphoid osteolysis". Retrieved 2012-08-17.


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