Obliterative portal venopathy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Synonyms and keywords: Hepatoportal sclerosis

Overview

Hepatoportal sclerosis (HPS) is a rare disorder characterized by sclerosis of the intrahepatic portal veins.

Pathophysiology

Pathology

Histopathologic findings are

  • Periportal fibrosis
  • Proliferation of small vascular channels within/around portal tracts

Causes

  • autoimmune and connective tissue diseases

Differentiating from other Diseases

Differential diagnosis from liver cirrhosis is crucial and may be difficult. A large liver biopsy specimen, together with expertise and awareness of the examiner, are requested for optimal diagnosis.

Epidemiology and Demographics

The prevalence of this disease is unknown, and the distribution is worldwide, with many cases reported in Asia.

Age

The disease can occur at any age.

Gender

Both males and females are equally affected.

Natural History, Complications and Prognosis

Complications

  • Liver failure
  • Ascites
  • Encephalopathy

Prognosis

Current overallprognosis is good (80% survival at ten years after the diagnosis). Male patients and patients with disease onset before 40 years of age show a poorer prognosis

Diagnosis

Symptoms

Physical Examination

Laboratory Findings

Treatment

References


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