Porphyromonas gingivalis
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor In Chief: Aarti Narayan
Overview
Porphyromonas gingivalis belongs to the Bacteroides genus and is a non-motile, gram-negative, rod-shaped, anaerobic pathogenic bacterium. It forms black colonies on blood agar. It is found in the oral cavity, where it is implicated in certain forms of periodontal disease, as well as the upper gastrointestinal tract, respiratory tract, and in the colon. Collagen degradation that is observed in Chronic Periodontal Disease results in part from the collagenase enzymes of this species.
P.gingivalis and Rheumatoid arthritis
- P.gingivalis is recognized to be a major pathogen in periodontitis and has been associated with Rheumatoid arthritis in numerous studies.[1] [2] [3]
- It is the only bacteria known to express the peptidylarginine deiminase enzyme(PAD), playing a major role in peptide citrullination.
- As the anti-cyclic citrullinated peptide antibodies (anti-CCP) are highly specific for Rheumatoid arthritis and correlate with its severity, the presence of periodontits with P.gingivalis has been thought to be associated with RA.[4]
- ↑ Dissick A, Redman RS, Jones M; et al. (2010). "Association of periodontitis with rheumatoid arthritis: a pilot study". Journal of Periodontology. 81 (2): 223–30. doi:10.1902/jop.2009.090309. PMID 20151800. Retrieved 2012-04-26. Unknown parameter
|month=ignored (help) - ↑ Mercado FB, Marshall RI, Klestov AC, Bartold PM (2001). "Relationship between rheumatoid arthritis and periodontitis". Journal of Periodontology. 72 (6): 779–87. doi:10.1902/jop.2001.72.6.779. PMID 11453241. Retrieved 2012-04-26. Unknown parameter
|month=ignored (help) - ↑ Marotte H, Farge P, Gaudin P, Alexandre C, Mougin B, Miossec P (2006). "The association between periodontal disease and joint destruction in rheumatoid arthritis extends the link between the HLA-DR shared epitope and severity of bone destruction". Annals of the Rheumatic Diseases. 65 (7): 905–9. doi:10.1136/ard.2005.036913. PMC 1798215. PMID 16284099. Retrieved 2012-04-26. Unknown parameter
|month=ignored (help) - ↑ McGraw WT, Potempa J, Farley D, Travis J (1999). "Purification, characterization, and sequence analysis of a potential virulence factor from Porphyromonas gingivalis, peptidylarginine deiminase". Infection and Immunity. 67 (7): 3248–56. PMC 116503. PMID 10377098. Retrieved 2012-04-26. Unknown parameter
|month=ignored (help)