Breast cancer bone metastasis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Assistant Editor(s)-In-Chief: Jack Khouri

Overview

Bone is the most common site of breast cancer recurrence [1], [2]. A Skeletal-Related event (sre)is defined as any of the following:

  • pathologic fracture,
  • a requirement for surgical intervention and palliative radiotherapy to bone lesions,
  • spinal cord compression
  • hypercalcemia of malignancy

SRE cause major morbidity, decrease survival and reduce quality of life.

References

  1. Coleman RE (2006). "Clinical features of metastatic bone disease and risk of skeletal morbidity". Clin Cancer Res. 12 (20 Pt 2): 6243s–6249s. doi:10.1158/1078-0432.CCR-06-0931. PMID 17062708.
  2. Coleman RE, Rubens RD (1987). "The clinical course of bone metastases from breast cancer". Br J Cancer. 55 (1): 61–6. PMC 2001575. PMID 3814476.

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