Hypertriglyceridemia omega-3 fatty acids
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [2]
Overview
Treatment of hypertriglyceridemia is by restriction of carbohydrates and fat in the diet, as well as with niacin, fibrates and statins (three classes of drugs). Increased fish oil intake may substantially lower an individual's triglycerides.[1][2][3].
Omega-3 fatty acids
Mechanism of benefit
- Decreased hepatic lipogenesis
- Increased plasma lipoprotein lipase activity.
- Increased hepatic mitochondrial and peroxisomal beta-oxidation
- Inhibition of acyl CoA:1,2-diacylglycerol acyltransferase enzyme
- Omega-3 fatty acids component EPA and DHA are poor enzyme substrates for triglyceride synthesis in the liver
- EPA and DHA inhibit esterification of other fatty acids.
References
- ↑ "Lipids Online Slides: hypertriglyceridemia, ICAM-1, fish oil, E-selectin".
- ↑ Terres W, Beil U, Reimann B, Tiede S, Bleifeld W (1991). "[Low-dose fish oil in primary hypertriglyceridemia. A randomized placebo-controlled study]". Zeitschrift für Kardiologie (in German). 80 (1): 20–4. PMID 2035283.
- ↑ "Fish oils in hypertriglyceridemia - Fish Oils Revisited Nutrition Research Newsletter - Find Articles".