Mexiletine

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Mexiletine
Clinical data
Pregnancy
category
  • AU: B1
  • US: C (Risk not ruled out)
Routes of
administration
Oral, IV
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability90%
Protein binding50-60%
MetabolismHepatic (CYP2D6 and 1A2- mediated)
Elimination half-life10-12 hours
ExcretionRenal (10%)
Identifiers
CAS Number
PubChem CID
DrugBank
E number{{#property:P628}}
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Chemical and physical data
FormulaC11H17NO
Molar mass179.259 g/mol

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

Mexiletine (INN, sold under the trade name Mexitil®) belongs to the Class IB anti-arrhythmic group of medicines. It is used to treat arrhythmias within the heart - or seriously irregular heartbeats. It slows nerve impulses in the heart and makes the heart tissue less sensitive. Dizziness, heartburn, nausea, nervousness, trembling, unsteadiness are common side effects. It is available in injection and capsule form.

Class IB antiarrhythmics decrease action potential duration by shortening the repolarization phase. This is achieved by blocking sodium channels[3].

Mexiletine may also be of use in patients experiencing refractory pain. (Sweetman, 2002) and is also effective for treating muscle stiffness resulting from myotonia congenita (Thomsen disease)

External links

References

  • Peck T (2004). Pharmacology for Anaesthesia and Intensive Care (2nd ed. ed.). Cambridge University Press. ISBN 0-521-68794-2. Unknown parameter |coauthors= ignored (help)
  • Sweetman S (ed.) (2002). Martindale: The complete drug reference (33rd ed. ed.). London: Pharmaceutical Press. ISBN 0-85369-499-0.


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