Weight loss resident survival guide

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Javaria Anwer M.D.[2]
Synonyms and keywords: weight loss management guide, unintentional weight loss management guide, loss of weight resident survival guide, pathologic weight loss resident survival guide.

Lymphadenopathy resident survival guide microchapters
Overview
Causes
Management
Do's
Don'ts

Overview

Weight loss may be intentional or unintentional.

Causes

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

• Life threatening cause 1
• Life threatening cause 2
• Life threatening cause 3

Common Causes

• Malignancies (specifically digestive and non-hematologic), dementia, stroke, parkinson's disease, polymyalgia rheumatica, and oral disorders are more prevalent among individuals >65 years old.
• Endocrine disorders, infections such as TB and HIV, psychiatric disorders such as depression, anxiety, OCD, and malignancies such as hematologic ones are more prevalent among patients, <65 years of age.
• The chart below demonstrates the cause of unintentional weight loss in adult population. The incidence describes the full range of occurrence described in five studies in older individuals.

Causes of weight loss

Intentional weight loss

Unintentional weight loss

Non-Malignant (~60%)

Malignant (19 - 39%) ❑ Gastrointestinal (53%) based on one study : Oesophageal cancer, stomach cancer, colon cancer, and rectal cancer. ❑ Renal: Renal cancer and renal pelvis cancer. ❑ Pulmonary: Bronchial cancer and lung cancer ❑ Hepato-pancreatic: HCC, pancreatic cancer, intra-hepatic bile duct cancer. ❑ Genitourinary: Ovarian cancer, cervical cancer, endometrial cancer, prostate cancer, ureter cancer, bladder cancer ❑ Hematologic: Hodgkin's lymphoma and Non-Hodgkin's lymphoma ❑ Breast cancer ❑ Malignant neoplasms

Infectious (2 - 8%) ❑ Chronic diarrhea ❑ Tuberculosis (TB) ❑ HIV ❑ infective endocarditis ❑ Infective colitis and gastroenteritis.

Autoimmune (2 - 7%) ❑ SLE ❑ Rheumatoid arthritis ❑ Polyarteritis nodosa ❑ Polymyalgia rheumatica ❑ Giant cell arteritis with polymyalgia rheumatica

Psychologic/ Psychiatric (9 - 42%) ❑ Depression ❑ Bipolar disorder ❑ Somatoform disorder ❑ Schizophrenia ❑ OCD ❑ Anxiety ❑ Dementia ❑ Social exclusion or rejection ❑ Neglect ❑ Disability

Organ system based ❑ Gastrointestinal (6 - 30%): Cholecystitis, Gastric and duodenal ulcers, IBD, celiac disease, malabsorption, steatorrhea, vascular disorders affecting intestines, non-infective gastroenteritis and colitis, swallowing pathologies, and dental issues. ❑ Renal (4%): Pyelonephritis, nephritic syndrome, and nephrotic syndrome ❑ Cardiopulmonary (2-10%): Heart failure, COPD, lung abscess (without pneumonia), interstitial lung disease (fibrotic or idiopathic), pleural effusion, and pyothorax (without fistula). ❑ Neurologic (2 - 7%): Stroke, parkinson's disease, and motor neuron disease. ❑ Endocrine (4 - 11%): Type I diabetes, type 2 diabetes, hyperthyroidism, primary hyperparathyroidism, Addison's disease, and subacute thyroiditis.

Drug-induced (6 - 8%) ❑ Narcotic analgesics (such as opioids) interfere with cognition and ability to eat ❑ Sedatives also interfere with cognition ❑ Psychedelic drugs ❑ Cocaine ❑ Alcohol (4 - 8%) ❑ SSRIs ❑ Psychotropic drug dose reduction ❑ Other drugs that cause vomiting, anorexia, dysphagia, and dysgeusia

Unexplained / Unknown (6 - 36%)

• To read about other causes of unintentional weight loss click here.

Diagnosis

Shown below is an algorithm summarizing the diagnosis of weight loss.

History ❑ Source of history: Patient or well-informed caregiver (elderly may be unaware or deny weight loss). ❑ Patient age: Helps determine age-specific causes, such as malignancy among the elderly. ❑ Duration of symptoms: (weeks in acute/severe versus years in chronic conditions). ❑ Associated symptoms: Assess if the patient is nauseated or vomiting/ anorexia/ dysphagia/ odynophagia/ social reasons hindering food supply. ❑ Nutritional status: ❑ Dietary history: Food availability, diet adequacy in the quantity (daily caloric intake), and quality (balance of nutrition), and nutritional supplements. ❑ Weight measurement records or best estimate of weight loss accessed by clothing size. ❑ Mini Nutritional Assessment: To assess the nutritional risk among the elderly. ❑ Assess the mental and functional status of the patient. ❑ Psychiatric illness screening. Geriatric Depression Scale may be utilized to assess for depression among elderly. ❑ Systemic review: Assess for cardiovascular, respiratory, renal, hepatic, and rheumatologic system. ❑ Past medical history: Helps assess the nutritional status. May suggest of immunodeficiency (recurrent infections), diagnosed malignancy, malabsorption (chronic diarrhea), HF, dyspepsia. ❑ Past surgical history: Helps assess nutritional status. ❑ Medication history: Assess the use of medications known to cause weight loss. Polypharmacy may cause anorexia or altered taste. ❑ Family history: Certain malignant disorders (breast cancer, ovarian cancer, colon cancer, or stomach cancer)) ❑ Social history: Tobacco, alcohol use, opioid, cocaine use ❑ Sexual history: Suggestive of HIV AIDS ❑ Exposure: Communicable infectious diseases/ travel to high-risk areas.

Physical exam Appearance of the patient Cachexia or surgical scar marks demonstrating previous malignancy treatment ❑ Vital signs ❑ Temperature: High-grade / low-grade fever may demonstrate infection. ❑ Heart rate: Tachycardia with regular pulse may demonstrate infection. ❑ Respiratory rate: Tachypnea may demonstrate respiratory system involvement (infection\ metastasis). ❑ Blood pressure: Chronic hypertension or hypotension (may indicate sepsis as a complication). ❑ Oxygen saturation: may be low if the respiratory system is affected. ❑ HEENT ❑ Cardiovascular examination ❑ Respiratory examination ❑ Gastrointestinal system exam includes oral examination, abdominal examination, and digital rectal exam. ❑ Splenomegaly) may demonstrate IM, hodgkin's/ non-Hodgkin's lymphoma, and sarcoidosis ❑ Extremities exam ❑ Skin exam: Evaluate for the lesions that indicate malignancy such as melanoma/ potential inoculation sites for germ such as traumatic lesions.

Labs ❑ CBC with differential ❑ ESR ❑ CMP ❑ Peripheral smaer ❑ LFTs Labs may be required at a later stage pf diagnosis

Treatment

Shown below is an algorithm summarizing the treatment of [[disease name]] according the the [...] guidelines.

Do's

• Perform a thorough physical exam to evaluate for cause of weight loss.

Don'ts

• The content in this section is in bullet points.

References

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