Sandbox:Hannan

Cortex	Product	Clinical manifestations		Dianosis				Gold standard	Other features
		Symptoms	Signs	Blood & Urine	Histopathological	Imaging	Others
Adenoma	Aldosterone	Headache Vision problems Muscle cramps Muscle weakness & cramps Numbness Temporary paralysis Polyuria and polydipsia	Hypertension Refractory hypertension	Hypokalemia Alkalosis ↑ Plasma aldosterone ↓ Plasma Renin ↑ ARR	Single or multiple nodules Encapsulated Abundant clear cytoplasm Uniforming nuclei Histopathology may resemble: ZF (large, lipid-laden clear cells) ZG (small, compact cells with moderate amount of lipid) ZR (lipid-sparse cytoplasm)	Adrenal mass or nodule Unilateral or bilateral adrenal atrophy Hypodense mass (CT) Iso and low FDG uptake compared with liver (FDG PET/CT) Hyperintense on in-phase and hypointense on oppose-phase (MRI)	Fludrocortisone Suppression Testing Oral Sodium Loading Saline Infusion Testing Captopril test Adrenal venous sampling Posture test Genetic testing Immunohistochemical staining	Fludrocortisone Suppression Testing	Glucocorticoid-Remediable Aldosteronism responds to glucocorticoids Higher cardiovascular and cerebrovascular morbidity
	Cortisol
	Sex steroids
	Mix
Carcinoma
Nodular Hyperplasia

Adrenal mass	Clinical manifestations		Diagnosis				Gold standard	Other features
	Symptoms	Signs	Blood & Urine	Histopathological	Imaging	Others