Sandbox:Hannan

Myeloproliferative neoplasms (MPN)	Clinical manifestations		Diagnosis												Other features
	Symptoms	Physical examination	Lab findings									Bone marrow biopsy	Gold standard	Other investigations
			WBCs							RBCs	Platelets
			Leukocytosis	Blasts	Left shift	Basophilia	Eosinophilia	Monocytosis	Others
Chronic myeloid leukemia (CML), BCR-ABL1+	Asymptomatic Non-specific Hyperviscosity related Anemia related Bleeding Infection	Splenomegaly (46–76%) Purpura Anemia related Priapism	Absolute leukocytosis (median of 100,000/µL)	Blasts usually <2%	Left shift with classic myelocyte bulge (myelocytes > metamyelocytes on the blood smear)	Absolute basophilia is almost always present	Absolute eosinophilia in 90% of patients	Often present		Anemia	Platelet count is usually normal or elevated but thrombocytopenia indicates advanced stage or an alternative diagnosis		Bone marrow aspirate and unilateral biopsy with conventional cytogenetics and flow cytometry
Chronic neutrophilic leukemia (CNL)
Polycythemia vera (PV)
Primary myelofibrosis (PMF) prefibrotic/early stage overt fibrotic stage
Essential thrombocythemia (ET)
Chronic eosinophilic leukemia, not otherwise specified (NOS)
MPN, unclassifiable
Mastocytosis

Other myeloid neoplasm and acute leukemia	Clinical manifestations		Diagnosis				Other features
	Symptoms	Physical examination	Lab findings	Bone marrow biopsy	Gold standard	Other investigations
Myeloid/lymphoid neoplasms with eosinophilia and rearrangement of PDGFRA, PDGFRB, or FGFR1, or with PCM1-JAK2 Myeloid/lymphoid neoplasms with PDGFRA rearrangement Myeloid/lymphoid neoplasms with PDGFRB rearrangement Myeloid/lymphoid neoplasms with FGFR1 rearrangement Provisional entity: Myeloid/lymphoid neoplasms with PCM1-JAK
Myelodysplastic/myeloproliferative neoplasms (MDS/MPN) Chronic myelomonocytic leukemia (CMML) Atypical chronic myeloid leukemia (aCML), BCR-ABL1- Juvenile myelomonocytic leukemia (JMML) MDS/MPN with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T) MDS/MPN, unclassifiable
Myelodysplastic syndromes (MDS) MDS with single lineage dysplasia MDS with ring sideroblasts (MDS-RS) MDS-RS and single lineage dysplasia MDS-RS and multilineage dysplasia MDS with multilineage dysplasia MDS with excess blasts MDS with isolated del(5q) MDS, unclassifiable Provisional entity: Refractory cytopenia of childhood Myeloid neoplasms with germ line predisposition
Acute myeloid leukemia (AML) and related neoplasms AML with recurrent genetic abnormalities AML with t(8;21)(q22;q22.1);RUNX1-RUNX1T1 AML with inv(16)(p13.1q22) or t(16;16)(p13.1;q22);CBFB-MYH11 APL with PML-RARA AML with t(9;11)(p21.3;q23.3);MLLT3-KMT2A AML with t(6;9)(p23;q34.1);DEK-NUP214 AML with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2);GATA2, MECOM AML (megakaryoblastic) with t(1;22)(p13.3;q13.3);RBM15-MKL1 Provisional entity: AML with BCR-ABL1 AML with mutated NPM1 AML with biallelic mutations of CEBPA Provisional entity: AML with mutated RUNX1 AML with myelodysplasia-related changes Therapy-related myeloid neoplasms AML, NOS AML with minimal differentiation AML without maturation AML with maturation Acute myelomonocytic leukemia Acute monoblastic/monocytic leukemia Pure erythroid leukemia Acute megakaryoblastic leukemia Acute basophilic leukemia Acute panmyelosis with myelofibrosis Myeloid sarcoma Myeloid proliferations related to Down syndrome Transient abnormal myelopoiesis (TAM) Myeloid leukemia associated with Down syndrome
Blastic plasmacytoid dendritic cell neoplasm
Acute leukemias of ambiguous lineage Acute undifferentiated leukemia Mixed phenotype acute leukemia (MPAL) with t(9;22)(q34.1;q11.2);BCR-ABL1 MPAL with t(v;11q23.3);KMT2A rearranged MPAL, B/myeloid, NOS MPAL, T/myeloid, NO
B-lymphoblastic leukemia/lymphoma B-lymphoblastic leukemia/lymphoma, NOS B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormalities B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2);BCR-ABL1 B-lymphoblastic leukemia/lymphoma with t(v;11q23.3);KMT2A rearranged B-lymphoblastic leukemia/lymphoma with t(12;21)(p13.2;q22.1);ETV6-RUNX1 B-lymphoblastic leukemia/lymphoma with hyperdiploidy B-lymphoblastic leukemia/lymphoma with hypodiploidy B-lymphoblastic leukemia/lymphoma with t(5;14)(q31.1;q32.3) IL3-IGH B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3);TCF3-PBX1 Provisional entity: B-lymphoblastic leukemia/lymphoma, BCR-ABL1–like Provisional entity: B-lymphoblastic leukemia/lymphoma with iAMP
T-lymphoblastic leukemia/lymphoma Provisional entity: Early T-cell precursor lymphoblastic leukemia Provisional entity: Natural killer (NK) cell lymphoblastic leukemia/lymph

• 50% of patients are asymptomatic

• Clinical features are generally nonspecific such as left upper quadrant pain, early satiety, fatigue & lethargy (most common presenting symptom), weight loss, and night sweats.
• symptoms of anemia
• bleeding
• priapism
• bone pain
• Abdominal mass or fullness
• Infection
• Headache
• Dyspnoea
• Visual disturbances
• Weakness
• Arthralgia
• Cough
• Malaise
• Dizziness
• Nausea/vomiting
• Ankle oedema
• Mental change