Pseudomyxoma peritonei causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
Pseudomyxoma peritonei is caused by a pre-existing intraperitoneal mucinous neoplasm. The K-Ras and p53 genes may be involved in the oncogenesis.
Causes
- Studies have shown and supported that pseudomyxoma peritonei arises from primary appendiceal neoplasm rather than ovarian or colon origin.[1]
- The primary tumor appears to arise from the MUC2 expressing goblet cells and most commonly from these cells in the appendix. [2]
- The K-Ras and p53 genes may be involved in the oncogenesis, it was shown in studies that overexpression of p53 is in correlation with female sex, higher-grade disease, and worse survival. [3]
- While the majority of pseudomyxoma peritonei are associated with appendiceal carcinomas, other conditions may also be found, including disseminated peritoneal adenomucinosis (DPAM), peritoneal carcinomas, or several mucinous tumors (mucinous adenocarcinoma, mucinous cystadenoma, and mucinous cystadenocarcinoma).[4]
References
- ↑ Carr NJ, Finch J, Ilesley IC, Chandrakumaran K, Mohamed F, Mirnezami A, Cecil T, Moran B (October 2012). "Pathology and prognosis in pseudomyxoma peritonei: a review of 274 cases". J. Clin. Pathol. 65 (10): 919–23. doi:10.1136/jclinpath-2012-200843. PMID 22718846.
- ↑ O'Connell JT, Tomlinson JS, Roberts AA, McGonigle KF, Barsky SH (August 2002). "Pseudomyxoma peritonei is a disease of MUC2-expressing goblet cells". Am. J. Pathol. 161 (2): 551–64. doi:10.1016/S0002-9440(10)64211-3. PMID 12163380.
- ↑ Shetty S, Thomas P, Ramanan B, Sharma P, Govindarajan V, Loggie B (March 2013). "Kras mutations and p53 overexpression in pseudomyxoma peritonei: association with phenotype and prognosis". J. Surg. Res. 180 (1): 97–103. doi:10.1016/j.jss.2012.10.053. PMID 23199549.
- ↑ Jacquemin G, Laloux P (2005). "Pseudomyxoma peritonei: review on a cluster of peritoneal mucinous diseases". Acta Chir Belg. 105 (2): 127–33. PMID 15906901.