SSMEM1

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Serine-rich single pass membrane protein 1 is a protein that in humans is encoded by the SSMEM1 gene.[1]

Gene

The gene and intron-exon structure were first predicted through analysis of the complete sequence of human chromosome 7, its initial designation being C7orf45.[2][3] Human mRNA transcripts were identified through two large scale cDNA cloning efforts, an American effort run out of the Dana-Farber Cancer Institute and Harvard Medical School, and full-length long Japan effort. Later assigned the official symbol SSMEM1, the gene is located on the long arm of chromosome 7 (7q32.2) on the sense strand in humans.[4] The human mRNA transcript is 1171 bp long with three exons.[5]

Aliases

In humans, SSMEM1 is also referred to as C7orf45.[4] Human SSMEM1 has a clone name of FLJ40316.[4]

Expression

In humans, SSMEM1 is highly expressed in the testes.[6][not in citation given][7][8] In mice, SSMEM1 is expressed in the brain.[9]

Protein

In humans, serine-rich single pass membrane protein 1 is 244 amino acids long with a transmembrane domain region spanning amino acids 35-55.[1] This protein has a domain of unknown function (DUF4636) that spans almost all of the protein (amino acids 1-243).[1] DUF4636 belongs to pfam15468 which is a part of the superfamily cl21285 that is found in eukaryotes and typically 196 to 244 amino acids long.[1] The human protein has a molecular weight of 28036 Da and an isoelectric point of 7.64.[1][10]

References

  1. 1.0 1.1 1.2 1.3 1.4 "serine-rich single-pass membrane protein 1 [Homo sapiens]". Protein. NCBI. 26 August 2016. NP_660311.1. Retrieved 2016-12-16.
  2. "Showing 9.782 kbp from Chr7, positions 129,233,084 to 129,242,865". The Chromosome 7 Annotation Project. June 2004. Landmark or Region: Gene:C7orf45|NM_145268.2. Retrieved 2016-12-16.
  3. Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–772. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
  4. 4.0 4.1 4.2 "SSMEM1 serine rich single-pass membrane protein 1 [ Homo sapiens (human) ]". Gene. NCBI. 6 December 2016. 136263. Retrieved 2016-12-16.
  5. "Homo sapiens serine rich single-pass membrane protein 1 (SSMEM1), mRNA". Nucleotide. NCBI. 26 August 2016. NM_145268.3. Retrieved 2016-12-16.
  6. http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/8586006
  7. "Est Profile - Hs.351816". UniGene. NCBI. 2016.
  8. "GDS3834 / 4246". www.ncbi.nlm.nih.gov. Retrieved 2016-12-17.
  9. "Gene Detail :: Allen Brain Atlas: Mouse Brain". mouse.brain-map.org. Retrieved 2016-12-17.
  10. "SSMEM1 (human)". www.phosphosite.org. Retrieved 2016-12-17.