ZFYVE16

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Zinc finger FYVE domain-containing protein 16 is a protein that in humans is encoded by the ZFYVE16 gene.[1][2]

The ZFYVE16 gene encodes endofin, an endosomal protein implicated in regulating membrane trafficking. It is characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain positioned in the middle of the molecule (Seet et al., 2004).[supplied by OMIM][2]

In melanocytic cells ZFYVE16 gene expression may be regulated by MITF.[3]

Interactions

ZFYVE16 has been shown to interact with TOM1.[4]

References

  1. Seet LF, Hong W (Nov 2001). "Endofin, an endosomal FYVE domain protein". J Biol Chem. 276 (45): 42445–54. doi:10.1074/jbc.M105917200. PMID 11546807.
  2. 2.0 2.1 "Entrez Gene: ZFYVE16 zinc finger, FYVE domain containing 16".
  3. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
  4. Seet, Li-Fong; Liu Ningsheng; Hanson Brendon J; Hong Wanjin (Feb 2004). "Endofin recruits TOM1 to endosomes". J. Biol. Chem. United States. 279 (6): 4670–9. doi:10.1074/jbc.M311228200. ISSN 0021-9258. PMID 14613930.

Further reading