Sandbox:Hannan
Molecular pathways and factors associated with osteoblastic activity | Association with multiple myeloma |
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Wingless and integration-1 (Wnt) signaling
Activation of Wnt pathway → binding of Wnt ligands to Wnt co-receptors LRP5/6 and one trans-membrane receptor of the FDZ family → formation of DVL–Axin–FRAT1–GSK-3β complex → translocation of β-catenin from cytoplasm to nucleus → activation of T cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors → ↑ bone formation and ↓ bone resorption
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Dickkopf 1 (Dkk-1)
Sclerostin
Secreted frizzled related protein-2 (sFRP-2)
Periostin
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Transforming Growth Factor-β
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