Urethral cancer pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Vindhya BellamKonda, M.B.B.S [2]

Overview

Urethral cancer is a rare disease. The pathophysiology of urethral cancer depends on the histological subtypes.

Pathogenesis

Mucous cells in the urethra have the ability to turnover rapidly. It has been suggested that defect in DNA repair mechanism may cause urethral cancer.

Chronic inflammation:

Infection: HPV type 16,

Irritation of the urethra:

Genetics

Gross Pathology

Microscopic Pathology

References

  1. Cantiello F, Cicione A, Salonia A, Autorino R, Tucci L, Madeo I, Damiano R (May 2013). "Periurethral fibrosis secondary to prostatic inflammation causing lower urinary tract symptoms: a prospective cohort study". Urology. 81 (5): 1018–23. doi:10.1016/j.urology.2013.01.053. PMID 23608423.