Lead poisoning differential diagnosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aksiniya K. Stevasarova, MD
Overview
Lead poisoning must be differentiated from megaloblastic anemia, carpal tunnel syndrome, Guillain–Barré syndrome, renal colic, appendicitis, encephalitis in adults, and viral gastroenteritis in children.[1], constipation, abdominal colic, iron deficiency, subdural hematoma, neoplasms of the central nervous system, emotional and behavior disorders, and intellectual disability.[2]
Differentiating Lead poisoning from other Diseases
- As lead poisoning manifests in a variety of clinical forms, differentiation must be established in accordance with the particular clinical symptom. For example sideroblastic anemia must be differentiated from other diseases that cause basophilic stippling like megaloblastic anemia.
Preferred Table
| Diseases | Clinical manifestations | Para-clinical findings | Gold standard | Additional findings | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Symptoms | colspan="3" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center; | Physical examination | |||||||||||||
| Lab Findings | Imaging | Histopathology | |||||||||||||
| basophilic stippling | colspan="1" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center; | Symptom 3 | Physical exam 1 | colspan="1" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center; | Physical examination 2 | Physical exam 3 | Lab 1 | Lab 2 | Lab 3 | Imaging 1 | Imaging 2 | Imaging 3 | |||
| Megaloblastic anemia | |||||||||||||||
| Guillain–Barré syndrome | |||||||||||||||
| Encephalitis | |||||||||||||||
| Diseases | Symptom 1 | Symptom 2 | Symptom 3 | Physical exam 1 | Physical exam 2 | Physical exam 3 | Lab 1 | Lab 2 | Lab 3 | Imaging 1 | Imaging 2 | Imaging 3 | Histopathology | Gold standard | Additional findings |
| Intellectual disability | |||||||||||||||
| Constipation | |||||||||||||||
| Viral gastroenteritis | |||||||||||||||