Wilms' tumor laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].
OR
Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].
OR
[Test] is usually normal for patients with [disease name].
OR
Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].
OR
There are no diagnostic laboratory findings associated with [disease name].
Laboratory Findings
- The following lab studies are conducted in patients suspected with wilms tumor:
- Complete blood count (CBC)
- Coagulation studies
- Von Willebrand assay
- Done in children with history of hypervascular disease or bleeding.
- Acquired von Willebrand's disease can be present in patients suffering from wilms tumor.[1]
- This is done as a precaution to risk of bleeding that can occur in case of interventions done for wilms tumor.
- Von Willebrand assay
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- Coagulation studies, including von Willebrand assay for acquired Von Willebrand disease (VWD), should be obtained in children who have a history of bleeding or hypervascular tumors because acquired von Willebrand's disease occurs in 4 to 8 percent of patients with Wilms tumors at diagnosis [61,62]. Although this abnormality usually has minimal clinical significance [63], there are case reports of severe bleeding requiring intensive intervention [64,65]. As a result, patients with a history of excessive bleeding should be screened for coagulopathy, and any abnormality should be corrected perioperatively [63,64]. (See "Acquired von Willebrand syndrome".)
- There are no diagnostic laboratory findings associated with [disease name].
OR
- An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].
- [Test] is usually normal among patients with [disease name].
- Laboratory findings consistent with the diagnosis of [disease name] include:
- [Abnormal test 1]
- [Abnormal test 2]
- [Abnormal test 3]
- Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].
- Laboratory studies include tests for renal function including urinalysis, liver function, serum calcium, a complete blood count, and coagulation studies. ●Serum creatinine is obtained to detect any reduction in glomerular filtration rate prior to surgical intervention. A urinalysis is sent to detect proteinuria, a finding that can occur in patients with Denys-Drash syndrome and mesangial sclerosis. (See 'Denys-Drash syndrome'above.) ●Liver function tests may be abnormal with liver metastases. ●Elevated serum calcium can be seen in children with rhabdoid tumor of the kidney or congenital mesoblastic nephroma [60]. (See 'Differential diagnosis' below.) ●
References
- ↑ Coppes MJ, Zandvoort SW, Sparling CR, Poon AO, Weitzman S, Blanchette VS (March 1992). "Acquired von Willebrand disease in Wilms' tumor patients". J. Clin. Oncol. 10 (3): 422–7. doi:10.1200/JCO.1992.10.3.422. PMID 1311024.