Undifferentiated connective tissue disease pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:
Overview
- The exact pathogenesis of undifferentiated connective tissue disorder(UCTD) is not fully understood. It is understood that UCTD is the result of autoimmune process and occurs in phases: Initial phase: which is asymptomatic and absence of auto-antibodies and second phase with the presence of auto-antibodies. The second phase is usually triggered by the environmental factors, such as infection. Auto-antibodies appear before the symptoms of the disease.The time between the two is variable. Autoantibodies usually seen in UCTD with positive correlation are antibodies against C1q ,Anti heat shock protein(hsp)-65, Anti hsp 60. The clinical picture involves the overlap of symptoms of other rhemautological disease but not completing the criteria of their diagnosis. More studies are needed to find the pathogenesis of UCTD.
Pathophysiology
Pathogenesis
- The exact pathogenesis of undifferentiated connective tissue disorder(UCTD) is not fully understood.[1]
- It is understood that UCTD is the result of autoimmune process and occurs in phases.[2]
- Initial phase: Asymptomatic and absence of auto-antibodies
- Second phase: Presence of auto-antibodies
- The second phase is usually triggered by the environmental factors, such as infection.
- Auto-antibodies appear before the symptoms of the disease.The time between the two is variable.
- Autoantibodies usually seen in UCTD with positive correlation are antibodies against:[3]
- C1q
- Anti heat shock protein(hsp)-65
- Anti hsp 60
- The clinical picture involves the overlap of symptoms of other rhemautological disease but not completing the criteria of their diagnosis.
- More studies are needed to find the pathogenesis of UCTD
Genetics
- [Disease name] is transmitted in [mode of genetic transmission] pattern.
- Genes involved in the pathogenesis of [disease name] include [gene1], [gene2], and [gene3].
- The development of [disease name] is the result of multiple genetic mutations.
Gross Pathology
- On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
Microscopic Pathology
- On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
References
- ↑ Mosca M, Neri R, Bombardieri S (1999). "Undifferentiated connective tissue diseases (UCTD): a review of the literature and a proposal for preliminary classification criteria". Clin. Exp. Rheumatol. 17 (5): 615–20. PMID 10544849.
- ↑ Bizzaro N, Tozzoli R, Shoenfeld Y (June 2007). "Are we at a stage to predict autoimmune rheumatic diseases?". Arthritis Rheum. 56 (6): 1736–44. doi:10.1002/art.22708. PMID 17530702.
- ↑ Horváth L, Czirják L, Fekete B, Jakab L, Prohászka Z, Cervenak L, Romics L, Singh M, Daha MR, Füst G (January 2001). "Levels of antibodies against C1q and 60 kDa family of heat shock proteins in the sera of patients with various autoimmune diseases". Immunol. Lett. 75 (2): 103–9. PMID 11137133.