RPH3AL

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Identifiers
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External IDs	GeneCards: [1]
Orthologs
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	Wikidata
View/Edit Human

Rab effector Noc2 is a protein that in humans is encoded by the RPH3AL gene.^[1]^[2]

Interactions

RPH3AL has been shown to interact with RAB27A.^[3]^[4]

References

↑ Smith JS, Tachibana I, Allen C, Chiappa SA, Lee HK, McIver B, Jenkins RB, Raffel C (Aug 1999). "Cloning of a human ortholog (RPH3AL) of (RNO)Rph3al from a candidate 17p13.3 medulloblastoma tumor suppressor locus". Genomics. 59 (1): 97–101. doi:10.1006/geno.1999.5864. PMID 10395805.
↑ "Entrez Gene: RPH3AL rabphilin 3A-like (without C2 domains)".
↑ Cheviet, Séverine; Coppola Thierry; Haynes Lee P; Burgoyne Robert D; Regazzi Romano (Jan 2004). "The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis". Mol. Endocrinol. United States. 18 (1): 117–26. doi:10.1210/me.2003-0300. ISSN 0888-8809. PMID 14593078.
↑ Fukuda, Mitsunori (Apr 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". J. Biol. Chem. United States. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. ISSN 0021-9258. PMID 12578829.

Kotake K, Ozaki N, Mizuta M, et al. (1997). "Noc2, a putative zinc finger protein involved in exocytosis in endocrine cells". J. Biol. Chem. 272 (47): 29407–10. doi:10.1074/jbc.272.47.29407. PMID 9367993.
Fenster SD, Chung WJ, Zhai R, et al. (2000). "Piccolo, a presynaptic zinc finger protein structurally related to bassoon". Neuron. 25 (1): 203–14. doi:10.1016/S0896-6273(00)80883-1. PMID 10707984.
Haynes LP, Evans GJ, Morgan A, Burgoyne RD (2001). "A direct inhibitory role for the Rab3-specific effector, Noc2, in Ca2+-regulated exocytosis in neuroendocrine cells". J. Biol. Chem. 276 (13): 9726–32. doi:10.1074/jbc.M006959200. PMID 11134008.
Goi T, Takeuchi K, Katayama K, et al. (2003). "Mutations of rabphillin-3A-like gene in colorectal cancers". Oncol. Rep. 9 (6): 1189–92. doi:10.3892/or.9.6.1189. PMID 12375017.
Milkereit P, Strauss D, Bassler J, et al. (2003). "A Noc complex specifically involved in the formation and nuclear export of ribosomal 40 S subunits". J. Biol. Chem. 278 (6): 4072–81. doi:10.1074/jbc.M208898200. PMID 12446671.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Fukuda M (2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". J. Biol. Chem. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. PMID 12578829.
Cardoso C, Leventer RJ, Ward HL, et al. (2003). "Refinement of a 400-kb Critical Region Allows Genotypic Differentiation between Isolated Lissencephaly, Miller-Dieker Syndrome, and Other Phenotypes Secondary to Deletions of 17p13.3". Am. J. Hum. Genet. 72 (4): 918–30. doi:10.1086/374320. PMC 1180354. PMID 12621583.
Cheviet S, Coppola T, Haynes LP, et al. (2004). "The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis". Mol. Endocrinol. 18 (1): 117–26. doi:10.1210/me.2003-0300. PMID 14593078.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Manabe S, Nishimura N, Yamamoto Y, et al. (2004). "Identification and characterization of Noc2 as a potential Rab3B effector protein in epithelial cells". Biochem. Biophys. Res. Commun. 316 (1): 218–25. doi:10.1016/j.bbrc.2004.02.026. PMID 15003533.
Matsumoto M, Miki T, Shibasaki T, et al. (2004). "Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells". Proc. Natl. Acad. Sci. U.S.A. 101 (22): 8313–8. doi:10.1073/pnas.0306709101. PMC 420391. PMID 15159548.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
1. Katkoori VR, Jia X, Chatla C, Kumar S, Ponnazhagan S, Callens T, Messiaen L, Grizzle WE, Manne U. (2008). "Clinical significance of a novel single nucleotide polymorphism in the 5′ untranslated region of the Rabphillin-3A-Like gene in colorectal adenocarcinoma". Frontiers in Bioscience. 13 (1): 1050–1061. doi:10.2741/2742. PMC 2667692. PMID 17981610. horizontal tab character in |author= at position 3 (help)

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[pmid10395805-1] Smith JS, Tachibana I, Allen C, Chiappa SA, Lee HK, McIver B, Jenkins RB, Raffel C (Aug 1999). "Cloning of a human ortholog (RPH3AL) of (RNO)Rph3al from a candidate 17p13.3 medulloblastoma tumor suppressor locus". Genomics. 59 (1): 97–101. doi:10.1006/geno.1999.5864. PMID 10395805.

[entrez-2] "Entrez Gene: RPH3AL rabphilin 3A-like (without C2 domains)".

[pmid14593078-3] Cheviet, Séverine; Coppola Thierry; Haynes Lee P; Burgoyne Robert D; Regazzi Romano (Jan 2004). "The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis". Mol. Endocrinol. United States. 18 (1): 117–26. doi:10.1210/me.2003-0300. ISSN 0888-8809. PMID 14593078.

[pmid12578829-4] Fukuda, Mitsunori (Apr 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". J. Biol. Chem. United States. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. ISSN 0021-9258. PMID 12578829.

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RPH3AL

Interactions

References

Further reading

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