Differentiating Alzheimer's disease from other diseases
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Alzheimer's disease may be differentiated from other causes of dementia based on characteristic clinical and cognitive features.
Differentiating Alzheimer's disease from other Diseases
- Alzheimer's disease may be differentiated from other causes of dementia based on characteristic clinical and cognitive features:
Cause of dementia | Clinical features | Associated features | Nature of progression | Histopathological findings | ||||||||||
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Cognitive impairment | ||||||||||||||
Recall | Recollection | Cue requirement for recall | Infirngement of thoughts | Semantic memory | Procedural memory | Working memory | Awareness | Attention | Executive functioning issues | Visuo-spatial skills | ||||
Alzheimer's disease | +++
(Slow cognitive and functional decline with early loss of awareness) |
+++ | Not helpful | +++ | ++ | - | ++ | +++ | ++ | ++ | ++ | Has the following clinical stages:
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Lewy body dementia | ++ | - | Helpful | +++ | + | + | +++ | + | +++ | +++ | +++ |
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Frontotemporal lobar degeneration | +/- | - | Helpful | +++ | + | - | +++ | +++ | ++ | +++ | - |
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Vascular dementia | + (Dysexecutive syndrome) | - | Helpful | + | + | + | ++ | - | ++ | +++ | + |
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