Sporotrichosis medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alison Leibowitz [2]

Treatment

Form Primary Line of Treatment Alternative Treatment Remarks/Other
Uncomplicated cutaneous Itraconazole [200 mg/day] Itraconazole [200 b.i.d.], terbinafine [500 b.i.d.], SSKI [increasing doses], fluconazole [400-800 mg/day], or local hyperthermia Continue treatment for 2-4 weeks after lesions resolve.
Osteoarticular Itraconazole [200 mg b.i.d.] Limposomal amphotericin B [3-5 mg/kg/day] or deoxycholate amphotericin B [0.7-1 mg/kg/day] until symptom resolution For a total of 12 months, switch to itraconazole after resolution/end of treatment.
Pulmonary Limposomal amphotericin B [3-5 mg/kg/day], followed by itraconazole [200 mg b.i.d.] Deoxycholate amphotericin B [0.7-1 mg/kg/day], followed by itraconazole [200 mg b.i.d.] upon symptom resolution Treat less sever cases with a 12 month regimen of itraconazole.
Meningeal Limposomal amphotericin B [3-5 mg/kg/day], followed by itraconazole [200 mg b.i.d.] Deoxycholate amphotericin B [0.7-1 mg/kg/day], followed by itraconazole [200 mg b.i.d.] upon symptom resolution Precise length of amphotericin B treatment varies. Suppressive treatment with itraconazole is necessary.
Dissimated Limposomal amphotericin B [3-5 mg/kg/day], followed by itraconazole [200 mg b.i.d.] Deoxycholate amphotericin B [0.7-1 mg/kg/day], followed by itraconazole [200 mg b.i.d.] upon symptom resolution Continue amphotericin B treatment until patient shows marked improvement for a minimum of 12 months. Suppressive treatment with itraconazole is necessary.
Sporotrichosis in pregnant women Treat with limposomal amphotericin B [3-5 mg/kg/day] or deoxycholate amphotericin B [0.7-1 mg/kg/day] only for severe cases of sporotrichosis.

In cases of uncomplicated cutaneous, treat with only hyperthermia.

It is preferable to defer treatment in uncomplicated cases.
Sporotrichosis in Children Itraconazole [6-10 mg/day to a max of 400 mg] for mild cases

Deoxycholate amphotericin B [0.7-1 mg/kg/day] for severe cases

SSKI [increasing doses equivalent to half the adult dose], continuing treatment for 2-4 weeks after resolution of symptoms.

[1]

References

  1. Kauffman CA, Bustamante B, Chapman SW, Pappas PG, Infectious Diseases Society of America (2007). "Clinical practice guidelines for the management of sporotrichosis: 2007 update by the Infectious Diseases Society of America". Clin Infect Dis. 45 (10): 1255–65. doi:10.1086/522765. PMID 17968818.