Neurofibroma pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]
Overview
Pathogenesis
- Neurofibromas arise from nonmyelinating-type Schwann cells.[1]
- Plexiform neurofibromas can grow from nerves in the skin or from more internal nerve bundles, and can be very large.[2]
- About 10% of plexiform neurofibromas undergo transformation into a malignant peripheral nerve sheath tumor (MPNST).[3]
Gross Pathology
Microscopic Pathology
Genetics
- NF1 is involved in the pathogenesis of plexiform neurofibroma.[4]
References
- ↑ Muir D, Neubauer D, Lim IT, Yachnis AT, Wallace MR. (2003). "Tumorigenic properties of neurofibromin-deficient neurofibroma Schwann cells". American Journal of Pathology. 158 (2): 501–13. doi:10.1016/S0002-9440(10)63992-2. PMC 1850316. PMID 11159187.
- ↑ Neurofibroma. Wikipedia 2015. https://en.wikipedia.org/wiki/Neurofibroma#cite_note-Yamashiroya2002-3
- ↑ Mautner VF, Friedrich RE, von Deimling A, Hagel C, Korf B, Knöfel MT, Wenzel R, Fünsterer C. (2003). "Malignant peripheral nerve sheath tumours in neurofibromatosis type 1: MRI supports the diagnosis of malignant plexiform neurofibroma". American Journal of Pathology. 45 (9): 618–25. doi:10.1007/s00234-003-0964-6. PMID 12898075.
- ↑ Kluwe L, Friedrich R, Mautner VF (1999). <283::AID-GCC15>3.0.CO;2-K "Loss of NF1 allele in Schwann cells but not in fibroblasts derived from an NF1-associated neurofibroma". Genes, Chromosomes & Cancer. 24 (3): 283–5. PMID 10451710. Retrieved 2015-11-13.