Essential thrombocytosis laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Lab tests for the diagnosis of Essential thrombocytosis include tests to rule out reactive or secondary causes of thrombocytosis and ET remains a diagnosis of exclusion. The tests include abnormal complete blood count (CBC), peripheral blood smear, cytogenetic studies including Philadelphia chromosome or BCR-ABL assay, and the presence of JAK2 V617F mutations. Bone marrow biopsy is an important test and needed to make a diagnosis of ET[1]as per WHO definition.
Laboratory findings
Lab tests for the diagnosis of Essential thrombocytosis include the following[2]:
- Complete blood count (CBC)
- Elevated platelet count
- Leukocytosis, erythrocytosis, and mild anemia may be present
- Peripheral blood smear shows large platelets, megakaryocyte fragments and platelet aggregates[3]
- To rule out inflammatory disorders
- Erythrocyte sedimentation rate (ESR)
- C-reactive protein (CRP)
- Fibrinogen
- To rule out Iron deficiency and polycythemia vera
- Serum ferritin
- Hematocrit
- To rule out other myeloproliferative neoplasms
- BCR-ABL or Philadelphia chromosome
- Genetic studies
- JAK2 mutation using PCR
- Bone marrow biopsy
- Increased cellularity
- Hyperplasia and clustering of megakaryocytes
- Bone marrow stains positive for iron
- Bone marrow reticulin may be increased with no collagen fibrosis
References
- ↑ Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID http://dx.doi.org/10.1182/blood-2007-04-083501 Check
|pmid=value (help). - ↑ Essential Thrombocytosis Workup. Medscape. http://emedicine.medscape.com/article/206697-workup#c8. Accessed on November 10th, 2015
- ↑ Essential Thrombocythemia. Merck manual. http://www.merckmanuals.com/professional/hematology-and-oncology/myeloproliferative-disorders/essential-thrombocythemia. Accessed on November 11,2015.