Subependymal giant cell astrocytoma natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Natural History
- Subependymal giant cell astrocytoma tends to grow slowly and are less likely to spread.[1]
- If left untreated, patients with subependymal giant cell astrocytoma may progress to cause occlusion of the foramen of Monro with subsequent elevated intracranial pressure and obstructive hydrocephalus.[2]
Complication
Common complications of subependymal giant cell astrocytoma include:[3]
- Obstructive hydrocephalus
- Intratumoral hemorrhage
- Infection
- Chronic ventriculoperitoneal shunt placement
- Stroke
- Sudden death
Prognosis
- Poor prognostic factors for subependymal giant cell astrocytoma include:[1]
- Invasion to neighboring structures (fornix, hypothalamus, basal ganglia, or genu of internal capsule)
- Large sized tumors
- Recurrent tumors
Reference
- ↑ 1.0 1.1 Roth, Jonathan; Roach, E. Steve; Bartels, Ute; Jóźwiak, Sergiusz; Koenig, Mary Kay; Weiner, Howard L.; Franz, David N.; Wang, Henry Z. (2013). "Subependymal Giant Cell Astrocytoma: Diagnosis, Screening, and Treatment. Recommendations From the International Tuberous Sclerosis Complex Consensus Conference 2012". Pediatric Neurology. 49 (6): 439–444. doi:10.1016/j.pediatrneurol.2013.08.017. ISSN 0887-8994.
- ↑ Clinical presentation of subependymal giant cell astrocytoma. Dr. Bruno Di Muzio and Dr. Jeremy Jones et al. Radiopaedia 2015. http://radiopaedia.org/articles/subependymal-giant-cell-astrocytoma. Accessed on November 2, 2015
- ↑ Surgery of subependymal giant cell astrocytoma. Wikipedia 2015. https://en.wikipedia.org/wiki/Subependymal_giant_cell_astrocytoma. Accessed on November 4, 2015