Carcinoid syndrome causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]

Overview

Majority of the cases of gastrointestinal carcinoid are sporadic, however gastrointestinal carcinoid is associated with mutations in MEN1 and NF1 genes.

Causes

  • In sporadic gastrointestinal carcinoids, numerous chromosomal imbalances have been found by comparative genome hybridization analysis. Gains involving chromosomes 5, 14, 17 (especially 17q), and 19 and losses involving chromosomes 11 (especially 11q) and 18 appear to be the most common.

References

  1. Molecular genetics . National Cancer Institute. http://www.cancer.gov/types/gi-carcinoid-tumors/hp/gi-carcinoid-treatment-pdq Accessed on September 22, 2015

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