Endometrial cancer classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]

Overview

Endometrial cancer may be classified according to histology into 7 subtypes: endometrioid, uterine papillary serous, mucinous, clear cell, squamous cell, mixed and undifferentiated.

Classification

  • Endometrial cancers are classified into either type 1 or type 2:[1]
  • Type 1 may arise from complex atypical hyperplasia and is pathogenetically linked to unopposed estrogenic stimulation.
  • Type 2 develops from atrophic endometrium and is not linked to hormonally driven pathogenesis.

Cellular Classification of Endometrial Cancer

1. Endometrioid (75%–80%)(The most common endometrial cancer cell type is endometrioid adenocarcinoma, which is composed of malignant glandular epithelial elements)
  • Ciliated adenocarcinoma
  • Secretory adenocarcinoma
  • Papillary or villoglandular
  • Adenocarcinoma with squamous differentiation
  • Adenoacanthoma
  • Adenosquamous (Adenosquamous tumors contain malignant elements of both glandular and squamous epithelium)
2. Uterine papillary serous (<10%)
3. Mucinous (1%)
4. Clear cell (4%)
5. Squamous cell (<1%)
6. Mixed (10%)
7. Undifferentiated

References

  1. "endometrial cancer classification".


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