Merkel cell cancer overview

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Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Merkel Cell Cancer from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Staging

History and Symptoms

Physical Examination

Laboratory Findings

CT

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]

Overview

Merkel cell cancer is a rare and highly aggressive cancer where malignant cancer cells develop on or just beneath the skin and in hair follicles. This cancer is a type of neuroendocrine tumor, like small cell lung cancer. Merkel cell carcinoma is the most serious form of skin cancer. Once it has metastasized to the lymph nodes, the 5-year survival rate for a patient is less than 50 percent. However, small tumors (less than 2 cm) that have not metastasized to the lymph nodes are associated with a 5-year survival rate of more than 90 percent. Recurrence may occur in up to half of all patients.[1] Merkel cell cancer usually manifests on either the face, head, or neck. Patients usually present with a rapid growing, firm, painless, red/violaceous skin lesion. It usually metastasizes first to regional lymph nodes and then to other distant organs. and spreads to other parts of the body, especially the liver, lungs, brain and bones. The predominant therapy for Merkel cell cancer is surgical resection, but adjuctive chemoradiation may also be required in more advanced disease.

Historical Perspective

Merkel cell polyomavirus, the pathogen responsible for Merkel cell cancer, was first discovered in 2008.[2]

Classification

Mercell cell carcinoma is classified into 3 subgroups: trabecular, intermediate, and small cell.

Pathophysiology

Causes

Merkel cell cancer is caused by Merkel cell polyomavirus (MCV) infection.

Differential Diagnosis

Merkel cell cancer must be differentiated from other skin lesions, such as basal cell carcinoma, squamous cell carcinoma, malignant melanoma, lymphoma, vascular tumors, and other benign skin tumors.

Epidemiology and Demographics

The incidence of Merkel cell carcinoma ranges from 0.15 to 0.44 per 100,000 individuals. The median age at diagnosis is approximately 65 years. Merkel cell carcinoma is more common among males and individuals of Caucasian race.

Risk Factors

Risk factors for the development of Merkel cell cancer include old age, male gender, Caucasian race, chronic exposure to sunlight, immunodeficiency, and personal history of cancer.

Screening

According to the the U.S. Preventive Service Task Force (USPSTF), there is insufficient evidence to recommend routine screening for skin cancers, including Merkel cell cancer.[3]

Natural History, Complications and Prognosis

Merkel cell carcinoma is a highly aggressive tumor with a mortality rate that approaches 30% to 40% within 3 years of diagnosis. If diagnosed early, Merkel cell cancer has a good prognosis with a 5-year survival rate of approximately 90%.

Diagnosis

Staging

The staging of Merkel cell cancer is based on the TNM staging system.

History and Symptoms

Patients with Merkel cell cancer usually present with a rapid growing, painless, small mass that is typically located on a sun exposed area of the body.

Physical Examination

Physical examination findings of Merkel cell cancer include a firm, dome-shaped or raised, red/violaceous skin mass that appear in sun exposed areas.

Laboratory Findings

There are no laboratory findings associated with Merkel cell cancer.

CT

CT scan is useful in detecting metastasis to organs and regional lymph nodes.

Other Imaging Findings

Positron emission tomography (PET) may be used in staging of Merkel cell cancer.

Other Diagnostic Studies

On biopsy, Merkel cell cancer is characterized by positivity on cytokeratin-20 immunohistochemical staining. On electron microscopy, the presence of neurosecretory granules within cytoplasmic extensions is characteristic.

Treatment

Medical Therapy

The predominant therapy for Merkel cell cancer is surgical resection. Adjunctive chemoradiation may also be required in more advanced disease.

Surgery

The majority of cases of Merkel cell cancer are treated with surgery.

Primary Prevention

Primary prevention of Merkel cell cancer includes avoidance of excessive sun exposure and use of sunscreen.

Secondary Prevention

Secondary prevention of Merkel cell cancer includes avoidance of excessive sun exposure and use of sunscreen.

References

  1. Allen PJ, Browne WB, Jaques DP; et al. (2005). "Merkel cell carcinoma: Prognosis and treatment of patients from a single institution". Journal of Clinical Oncology. 23 (10): 2300–2309.
  2. Spurgeon ME, Lambert PF (2013). "Merkel cell polyomavirus: a newly discovered human virus with oncogenic potential". Virology. 435 (1): 118–30. doi:10.1016/j.virol.2012.09.029. PMC 3522868. PMID 23217622.
  3. "USPSTF Skin Cancer Screening". Retrieved 20/8/2015. Check date values in: |access-date= (help)


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