Sandbox carlos

• Human herpesvirus 8 (KSHV) Return to Top

• 1. Mild to moderate Kaposi sarcoma

• Preferred regimen: initiate or optimize ART

• 2. Advanced Kaposi sarcoma (ACTG Stage T1, including disseminated cutaneous or visceral Kaposi sarcoma)

• Preferred regimen: chemotherapy (per oncology consult) AND ART

• 3. Primary effusion lymphoma

• Preferred regimen: chemotherapy (per oncology consult) AND ART
• Note: Valganciclovir PO or Ganciclovir IV can be used as adjunctive therapy.

• 4. Multicentric Castleman's disease

• Preferred regimen (1): Valganciclovir 900 mg PO bid for 3 weeks
• Preferred regimen (2): Ganciclovir 5 mg/kg IV q12h for 3 weeks
• Preferred regimen (3): Valganciclovir 900 mg PO BID AND Zidovudine 600 mg PO q6h for 7–21 days
• Alternative regimen: Rituximab 375 mg/m2 given weekly for 4–8 weeks (may be an alternative to or used adjunctively with antiviral therapy)