Terconazole microbiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Zaghw, M.D. [2]

Microbiology

Terconazole exhibits fungicidal activity in vitro against Candida albicans. Antifungal activity has also been demonstrated against other fungi. The MIC values of terconazole against most Lactobacillus spp. typically found in the human vagina were ≥128 mcg/mL; therefore these beneficial bacteria are not affected by drug treatment.

The exact pharmacologic mode of action of terconazole is uncertain; however, it may exert its antifungal activity by the disruption of normal fungal cell membrane permeability. No resistance to terconazole has developed during successive passages of C. albicans.[1]

References

  1. "TERAZOL 7 (TERCONAZOLE) CREAM TERAZOL 3 (TERCONAZOLE) CREAM TERAZOL 3 (TERCONAZOLE) SUPPOSITORY [JANSSEN PHARMACEUTICALS, INC.]".

Adapted from the FDA Package Insert.