Polycythemia vera epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2] Shyam Patel [3]

Overview

The incidence of polycythemia vera is approximately 0.7 to 2.6 per 100,000 individuals in the US.[1]

Epidemiology and Demographics

Incidence

The incidence of polycythemia vera is approximately 0.7 to 2.6 per 100,000 individuals in the US.[1]

Prevalence

The prevalence of polycythemia vera is 48 to 57 cases per 100,000 individuals in the United States. This represents the age-adjusted prevalence as of 2010. The prevalence of polycythemia vera is 5 to 30 cases per 100,000 individuals in Europe.[2] Approximately 148,000 persons are living with polycythemia vera currently.[3] It is likely that this is an underestimate of the true prevalence, as many patients are asymptomatic.[3]

Age

The average age of polycythemia vera is 55 years.[2] Polycythemia vera occurs in all age groups (including children). The incidence increases with age. Polycythemia vera commonly affects people older than 60.[1][4][5]

Gender

Males are more commonly affected with polycythemia vera than females, with a male to female ratio of 6.5:3.5.[1][2][2]

Life expectancy

The life expectancy after diagnosis is 13.5 years.[2]

References

  1. 1.0 1.1 1.2 1.3 National Cancer Institute. Polycythemia vera 2015.http://seer.cancer.gov/seertools/hemelymph/51f6cf57e3e27c3994bd538d/
  2. 2.0 2.1 2.2 2.3 2.4 Verstovsek S, Komrokji RS (2015). "Novel and emerging therapies for the treatment of polycythemia vera". Expert Rev Hematol. 8 (1): 101–13. doi:10.1586/17474086.2015.972359. PMC 4934659. PMID 25353086.
  3. 3.0 3.1 Stein BL, Oh ST, Berenzon D, Hobbs GS, Kremyanskaya M, Rampal RK; et al. (2015). "Polycythemia Vera: An Appraisal of the Biology and Management 10 Years After the Discovery of JAK2 V617F". J Clin Oncol. 33 (33): 3953–60. doi:10.1200/JCO.2015.61.6474. PMC 4979103. PMID 26324368.
  4. Passamonti F, Malabarba L, Orlandi E, Baratè C, Canevari A, Brusamolino E, Bonfichi M, Arcaini L, Caberlon S, Pascutto C, Lazzarino M (2003). "Polycythemia vera in young patients: a study on the long-term risk of thrombosis, myelofibrosis and leukemia". Haematologica. 88 (1): 13–8. PMID 12551821.
  5. Berlin, NI. (1975). "Diagnosis and classification of polycythemias". Semin Hematol 12: 339.

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