TNFAIP3
| Tumor necrosis factor, alpha-induced protein 3 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | TNFAIP3 ; A20; MGC104522; MGC138687; MGC138688; OTUD7C; TNFA1P2 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 4582 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE TNFAIP3 202644 s at tn.png | |||||||||||
| File:PBB GE TNFAIP3 202643 s at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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Tumor necrosis factor, alpha-induced protein 3, also known as TNFAIP3, is a human gene.[1]
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. Knockout studies of a similar gene in mice suggested that this gene is critical for limiting inflammation by terminating TNF-induced NF-kappa B responses.[1]
References
Further reading
- Opipari AW, Boguski MS, Dixit VM (1990). "The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein". J. Biol. Chem. 265 (25): 14705–8. PMID 2118515.
- Dixit VM, Green S, Sarma V; et al. (1990). "Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin". J. Biol. Chem. 265 (5): 2973–8. PMID 2406243.
- Cooper JT, Stroka DM, Brostjan C; et al. (1996). "A20 blocks endothelial cell activation through a NF-kappaB-dependent mechanism". J. Biol. Chem. 271 (30): 18068–73. PMID 8663499.
- Song HY, Rothe M, Goeddel DV (1996). "The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6721–5. PMID 8692885.
- Vincenz C, Dixit VM (1996). "14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules". J. Biol. Chem. 271 (33): 20029–34. PMID 8702721.
- De Valck D, Heyninck K, Van Criekinge W; et al. (1996). "A20, an inhibitor of cell death, self-associates by its zinc finger domain". FEBS Lett. 384 (1): 61–4. PMID 8797804.
- De Valck D, Heyninck K, Van Criekinge W; et al. (1997). "A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins". Biochem. Biophys. Res. Commun. 238 (2): 590–4. doi:10.1006/bbrc.1997.7343. PMID 9299557.
- Eliopoulos AG, Blake SM, Floettmann JE; et al. (1999). "Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme C terminus via a mechanism involving TRADD and TRAF2". J. Virol. 73 (2): 1023–35. PMID 9882303.
- Heyninck K, Beyaert R (1999). "The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6". FEBS Lett. 442 (2–3): 147–50. PMID 9928991.
- Heyninck K, De Valck D, Vanden Berghe W; et al. (1999). "The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN". J. Cell Biol. 145 (7): 1471–82. PMID 10385526.
- De Valck D, Jin DY, Heyninck K; et al. (1999). "The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases". Oncogene. 18 (29): 4182–90. doi:10.1038/sj.onc.1202787. PMID 10435631.
- Zhang SQ, Kovalenko A, Cantarella G, Wallach D (2000). "Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation". Immunity. 12 (3): 301–11. PMID 10755617.
- Lee EG, Boone DL, Chai S; et al. (2000). "Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice". Science. 289 (5488): 2350–4. PMID 11009421.
- Klinkenberg M, Van Huffel S, Heyninck K, Beyaert R (2001). "Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions". FEBS Lett. 498 (1): 93–7. PMID 11389905.
- Van Huffel S, Delaei F, Heyninck K; et al. (2001). "Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2". J. Biol. Chem. 276 (32): 30216–23. doi:10.1074/jbc.M100048200. PMID 11390377.
- Evans PC, Taylor ER, Coadwell J; et al. (2001). "Isolation and characterization of two novel A20-like proteins". Biochem. J. 357 (Pt 3): 617–23. PMID 11463333.
- Baltathakis I, Alcantara O, Boldt DH (2001). "Expression of different NF-kappaB pathway genes in dendritic cells (DCs) or macrophages assessed by gene expression profiling". J. Cell. Biochem. 83 (2): 281–90. PMID 11573245.
- Zetoune FS, Murthy AR, Shao Z; et al. (2002). "A20 inhibits NF-kappa B activation downstream of multiple Map3 kinases and interacts with the I kappa B signalosome". Cytokine. 15 (6): 282–98. doi:10.1006/cyto.2001.0921. PMID 11594795.
- Wu WS, Xu ZX, Chang KS (2002). "The promyelocytic leukemia protein represses A20-mediated transcription". J. Biol. Chem. 277 (35): 31734–9. doi:10.1074/jbc.M201648200. PMID 12080044.
- He KL, Ting AT (2002). "A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells". Mol. Cell. Biol. 22 (17): 6034–45. PMID 12167698.
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