HEXIM1
| Hexamethylene bis-acetamide inducible 1 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | HEXIM1 ; EDG1; HIS1; CLP1; FLJ13562; MAQ1 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 31382 | ||||||||||
| |||||||||||
| RNA expression pattern | |||||||||||
 | |||||||||||
 | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Hexamethylene bis-acetamide inducible 1, also known as HEXIM1, is a human gene.[1]
Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns.[1]
References
Further reading
- Wolff A (1976). "[Problem of occupational disability hazards]". Lebensversicherungs Medizin. 28 (3): 76–7. PMID 9544.
- Dias Neto E, Correa RG, Verjovski-Almeida S; et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.
- Huang F, Wagner M, Siddiqui MA (2002). "Structure, expression, and functional characterization of the mouse CLP-1 gene". Gene. 292 (1–2): 245–59. PMID 12119119.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Ouchida R, Kusuhara M, Shimizu N; et al. (2003). "Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells". Genes Cells. 8 (2): 95–107. PMID 12581153.
- Michels AA, Nguyen VT, Fraldi A; et al. (2003). "MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner". Mol. Cell. Biol. 23 (14): 4859–69. PMID 12832472.
- Yik JH, Chen R, Nishimura R; et al. (2003). "Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA". Mol. Cell. 12 (4): 971–82. PMID 14580347.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Paushkin SV, Patel M, Furia BS; et al. (2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell. 117 (3): 311–21. PMID 15109492.
- Yik JH, Chen R, Pezda AC; et al. (2004). "A human immunodeficiency virus type 1 Tat-like arginine-rich RNA-binding domain is essential for HEXIM1 to inhibit RNA polymerase II transcription through 7SK snRNA-mediated inactivation of P-TEFb". Mol. Cell. Biol. 24 (12): 5094–105. doi:10.1128/MCB.24.12.5094-5105.2004. PMID 15169877.
- Michels AA, Fraldi A, Li Q; et al. (2005). "Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor". EMBO J. 23 (13): 2608–19. doi:10.1038/sj.emboj.7600275. PMID 15201869.
- Yik JH, Chen R, Pezda AC, Zhou Q (2005). "Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription". J. Biol. Chem. 280 (16): 16368–76. doi:10.1074/jbc.M500912200. PMID 15713661.
- Byers SA, Price JP, Cooper JJ; et al. (2005). "HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK". J. Biol. Chem. 280 (16): 16360–7. doi:10.1074/jbc.M500424200. PMID 15713662.
- Schulte A, Czudnochowski N, Barboric M; et al. (2005). "Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 Tat". J. Biol. Chem. 280 (26): 24968–77. doi:10.1074/jbc.M501431200. PMID 15855166.
- Wittmann BM, Fujinaga K, Deng H; et al. (2005). "The breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1". Oncogene. 24 (36): 5576–88. doi:10.1038/sj.onc.1208728. PMID 15940264.
- Shimizu N, Ouchida R, Yoshikawa N; et al. (2005). "HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b.". Proc. Natl. Acad. Sci. U.S.A. 102 (24): 8555–60. doi:10.1073/pnas.0409863102. PMID 15941832.
- Li Q, Price JP, Byers SA; et al. (2005). "Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186". J. Biol. Chem. 280 (31): 28819–26. doi:10.1074/jbc.M502712200. PMID 15965233.
- Fraldi A, Varrone F, Napolitano G; et al. (2006). "Inhibition of Tat activity by the HEXIM1 protein". Retrovirology. 2: 42. doi:10.1186/1742-4690-2-42. PMID 15992410.
- Dulac C, Michels AA, Fraldi A; et al. (2005). "Transcription-dependent association of multiple positive transcription elongation factor units to a HEXIM multimer". J. Biol. Chem. 280 (34): 30619–29. doi:10.1074/jbc.M502471200. PMID 15994294.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
 | This protein-related article is a stub. You can help Wikipedia by expanding it. |