HBE1

Hemoglobin, epsilon 1
PDB rendering based on 1a9w.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1a9w​
Identifiers
Symbols	HBE1 ; HBE
External IDs	Template:OMIM5 Template:MGI HomoloGene: 74550
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Hemoglobin, epsilon 1, also known as HBE1, is a human gene.

The epsilon globin gene (HBE) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains (an alpha-like globin) constitute the embryonic hemoglobin Hb Gower I; two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic hemoglobins are normally supplanted by fetal, and later, adult hemoglobin. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon - G-gamma - A-gamma - delta - beta-3'

See also

• hemoglobin
• Human β-globin locus

Further reading

• Higgs DR, Vickers MA, Wilkie AO; et al. (1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood. 73 (5): 1081–104. PMID 2649166.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clegg JB (1982). "Embryonic hemoglobin: sequence of the epsilon and zeta chains". Tex. Rep. Biol. Med. 40: 23–8. PMID 6172865.
• Giardina B, Messana I, Scatena R, Castagnola M (1995). "The multiple functions of hemoglobin". Crit. Rev. Biochem. Mol. Biol. 30 (3): 165–96. PMID 7555018.CS1 maint: Multiple names: authors list (link)
• Chang JC, Kan YW (1979). "beta 0 thalassemia, a nonsense mutation in man". Proc. Natl. Acad. Sci. U.S.A. 76 (6): 2886–9. PMID 88735.
• Proudfoot NJ, Baralle FE (1980). "Molecular cloning of human epsilon-globin gene". Proc. Natl. Acad. Sci. U.S.A. 76 (11): 5435–9. PMID 160554.
• Proudfoot NJ, Brownlee GG (1976). "3' non-coding region sequences in eukaryotic messenger RNA". Nature. 263 (5574): 211–4. PMID 822353.
• Marotta CA, Forget BG, Cohne-Solal M; et al. (1977). "Human beta-globin messenger RNA. I. Nucleotide sequences derived from complementary RNA". J. Biol. Chem. 252 (14): 5019–31. PMID 873928.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gelinas R, Endlich B, Pfeiffer C; et al. (1985). "G to A substitution in the distal CCAAT box of the A gamma-globin gene in Greek hereditary persistence of fetal haemoglobin". Nature. 313 (6000): 323–5. PMID 2578619.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Collins FS, Metherall JE, Yamakawa M; et al. (1985). "A point mutation in the A gamma-globin gene promoter in Greek hereditary persistence of fetal haemoglobin". Nature. 313 (6000): 325–6. PMID 2578620.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lang KM, Spritz RA (1985). "Cloning specific complete polyadenylylated 3'-terminal cDNA segments". Gene. 33 (2): 191–6. PMID 2581851.
• Ley TJ, Maloney KA, Gordon JI, Schwartz AL (1989). "Globin gene expression in erythroid human fetal liver cells". J. Clin. Invest. 83 (3): 1032–8. PMID 2921315.CS1 maint: Multiple names: authors list (link)
• Chabot B, Black DL, LeMaster DM, Steitz JA (1986). "The 3' splice site of pre-messenger RNA is recognized by a small nuclear ribonucleoprotein". Science. 230 (4732): 1344–9. PMID 2933810.CS1 maint: Multiple names: authors list (link)
• Engelke DR, Hoener PA, Collins FS (1988). "Direct sequencing of enzymatically amplified human genomic DNA". Proc. Natl. Acad. Sci. U.S.A. 85 (2): 544–8. PMID 3267215.CS1 maint: Multiple names: authors list (link)
• Fei YJ, Stoming TA, Efremov GD; et al. (1988). "Beta-thalassemia due to a T----A mutation within the ATA box". Biochem. Biophys. Res. Commun. 153 (2): 741–7. PMID 3382401.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Prchal JT, Cashman DP, Kan YW (1986). "Hemoglobin Long Island is caused by a single mutation (adenine to cytosine) resulting in a failure to cleave amino-terminal methionine". Proc. Natl. Acad. Sci. U.S.A. 83 (1): 24–7. PMID 3455755.CS1 maint: Multiple names: authors list (link)
• van Santen VL, Spritz RA (1985). "mRNA precursor splicing in vivo: sequence requirements determined by deletion analysis of an intervening sequence". Proc. Natl. Acad. Sci. U.S.A. 82 (9): 2885–9. PMID 3857622.
• Ruskin B, Greene JM, Green MR (1985). "Cryptic branch point activation allows accurate in vitro splicing of human beta-globin intron mutants". Cell. 41 (3): 833–44. PMID 3879973.CS1 maint: Multiple names: authors list (link)
• Tuan D, Solomon W, Li Q, London IM (1985). "The "beta-like-globin" gene domain in human erythroid cells". Proc. Natl. Acad. Sci. U.S.A. 82 (19): 6384–8. PMID 3879975.CS1 maint: Multiple names: authors list (link)
• Orkin SH, Antonarakis SE, Kazazian HH (1984). "Base substitution at position -88 in a beta-thalassemic globin gene. Further evidence for the role of distal promoter element ACACCC". J. Biol. Chem. 259 (14): 8679–81. PMID 6086605.CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.