RAD18
| RAD18 homolog (S. cerevisiae) | |||||||||||
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| Identifiers | |||||||||||
| Symbols | RAD18 ; RNF73 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 48572 | ||||||||||
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| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
RAD18 homolog (S. cerevisiae), also known as RAD18, is a human gene.[1]
The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is a ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens.[1]
References
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
- Tateishi S, Sakuraba Y, Masuyama S; et al. (2000). "Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 7927–32. PMID 10884424.
- Xin H, Lin W, Sumanasekera W; et al. (2000). "The human RAD18 gene product interacts with HHR6A and HHR6B". Nucleic Acids Res. 28 (14): 2847–54. PMID 10908344.
- Mulder LC, Chakrabarti LA, Muesing MA (2002). "Interaction of HIV-1 integrase with DNA repair protein hRad18". J. Biol. Chem. 277 (30): 27489–93. doi:10.1074/jbc. M203061200 Check
|doi=value (help). PMID 12016221. - Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Nikiforov AA, Sasina LK, Svetlova MP; et al. (2004). "Early immobilization of nuclease FEN1 and accumulation of hRAD18 protein at stalled DNA replication forks in mammalian cells". Dokl. Biochem. Biophys. 389: 122–5. PMID 12856420.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
- Watanabe K, Tateishi S, Kawasuji M; et al. (2005). "Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination". EMBO J. 23 (19): 3886–96. doi:10.1038/sj.emboj.7600383. PMID 15359278.
- Nikiforov A, Svetlova M, Solovjeva L; et al. (2004). "DNA damage-induced accumulation of Rad18 protein at stalled replication forks in mammalian cells involves upstream protein phosphorylation". Biochem. Biophys. Res. Commun. 323 (3): 831–7. doi:10.1016/j.bbrc.2004.08.165. PMID 15381075.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Miyase S, Tateishi S, Watanabe K; et al. (2005). "Differential regulation of Rad18 through Rad6-dependent mono- and polyubiquitination". J. Biol. Chem. 280 (1): 515–24. doi:10.1074/jbc. M409219200 Check
|doi=value (help). PMID 15509568. - Masuyama S, Tateishi S, Yomogida K; et al. (2005). "Regulated expression and dynamic changes in subnuclear localization of mammalian Rad18 under normal and genotoxic conditions". Genes Cells. 10 (8): 753–62. doi:10.1111/j.1365-2443.2005.00874.x. PMID 16098139.
- Nousiainen M, Silljé HH, Sauer G; et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMID 16565220.
- Bi X, Barkley LR, Slater DM; et al. (2006). "Rad18 regulates DNA polymerase kappa and is required for recovery from S-phase checkpoint-mediated arrest". Mol. Cell. Biol. 26 (9): 3527–40. doi:10.1128/MCB.26.9.3527-3540.2006. PMID 16611994.
- Lloyd AG, Tateishi S, Bieniasz PD; et al. (2006). "Effect of DNA repair protein Rad18 on viral infection". PLoS Pathog. 2 (5): e40. doi:10.1371/journal.ppat.0020040. PMID 16710452.
- Yuasa MS, Masutani C, Hirano A; et al. (2006). "A human DNA polymerase eta complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest". Genes Cells. 11 (7): 731–44. doi:10.1111/j.1365-2443.2006.00974.x. PMID 16824193.
- Beausoleil SA, Villén J, Gerber SA; et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
- Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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