EIF2B4

Eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
Identifiers
Symbols	EIF2B4 ; EIF-2B; EIF2B; DKFZp586J0119; EIF2Bdelta
External IDs	Template:OMIM5 Template:MGI HomoloGene: 5976
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa, also known as EIF2B4, is a human gene.

Further reading

• Henderson RA, Krissansen GW, Yong RY; et al. (1994). "The delta-subunit of murine guanine nucleotide exchange factor eIF-2B. Characterization of cDNAs predicts isoforms differing at the amino-terminal end". J. Biol. Chem. 269 (48): 30517–23. PMID 7982969.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Welsh GI, Miyamoto S, Price NT; et al. (1996). "T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3". J. Biol. Chem. 271 (19): 11410–3. PMID 8626696.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang W, Hinnebusch AG (1996). "Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2". Mol. Cell. Biol. 16 (11): 6603–16. PMID 8887689.
• Price NT, Mellor H, Craddock BL; et al. (1996). "eIF2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2. Sequence conservation between the alpha, beta and delta subunits of eIF2B from mammals and yeast". Biochem. J. 318 ( Pt 2): 637–43. PMID 8929216.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimball SR, Heinzinger NK, Horetsky RL, Jefferson LS (1998). "Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B". J. Biol. Chem. 273 (5): 3039–44. PMID 9446619.CS1 maint: Multiple names: authors list (link)
• Gomez E, Pavitt GD (2000). "Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon) required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation". Mol. Cell. Biol. 20 (11): 3965–76. PMID 10805739.
• Anthony TG, Fabian JR, Kimball SR, Jefferson LS (2000). "Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation". Biochim. Biophys. Acta. 1492 (1): 56–62. PMID 10858531.CS1 maint: Multiple names: authors list (link)
• Hu RM, Han ZG, Song HD; et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMID 10931946.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Williams DD, Price NT, Loughlin AJ, Proud CG (2001). "Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein". J. Biol. Chem. 276 (27): 24697–703. doi:10.1074/jbc.M011788200. PMID 11323413.CS1 maint: Multiple names: authors list (link)
• van der Knaap MS, Leegwater PA, Könst AA; et al. (2002). "Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter". Ann. Neurol. 51 (2): 264–70. PMID 11835386.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fogli A, Dionisi-Vici C, Deodato F; et al. (2003). "A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation". Neurology. 59 (12): 1966–8. PMID 12499492.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kobayashi H, Børsheim E, Anthony TG; et al. (2003). "Reduced amino acid availability inhibits muscle protein synthesis and decreases activity of initiation factor eIF2B". Am. J. Physiol. Endocrinol. Metab. 284 (3): E488–98. doi:10.1152/ajpendo.00094.2002. PMID 12556349.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fogli A, Rodriguez D, Eymard-Pierre E; et al. (2003). "Ovarian failure related to eukaryotic initiation factor 2B mutations". Am. J. Hum. Genet. 72 (6): 1544–50. PMID 12707859.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• van der Knaap MS, van Berkel CG, Herms J; et al. (2004). "eIF2B-related disorders: antenatal onset and involvement of multiple organs". Am. J. Hum. Genet. 73 (5): 1199–207. PMID 14566705.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fogli A, Schiffmann R, Hugendubler L; et al. (2005). "Decreased guanine nucleotide exchange factor activity in eIF2B-mutated patients". Eur. J. Hum. Genet. 12 (7): 561–6. doi:10.1038/sj.ejhg.5201189. PMID 15054402.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li W, Wang X, Van Der Knaap MS, Proud CG (2004). "Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways". Mol. Cell. Biol. 24 (8): 3295–306. PMID 15060152.CS1 maint: Multiple names: authors list (link)
• Van Haren K, van der Voorn JP, Peterson DR; et al. (2004). "The life and death of oligodendrocytes in vanishing white matter disease". J. Neuropathol. Exp. Neurol. 63 (6): 618–30. PMID 15217090.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fogli A, Gauthier-Barichard F, Schiffmann R; et al. "Screening for known mutations in EIF2B genes in a large panel of patients with premature ovarian failure". BMC women's health [electronic resource]. 4 (1): 8. doi:10.1186/1472-6874-4-8. PMID 15507143.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)