Congenital rubella syndrome laboratory findings

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Overview

Diagnostic tests used to confirm congenital rubella syndrome include serologic assays and detection of rubella virus using real time PCR.

Laboratory Findings

Serologic Testing

The serologic tests available for laboratory confirmation of CRS infections vary among laboratories. Enzyme immunoassays (EIA) are the most commonly used and widely available diagnostic test for rubella IgG and IgM antibodies. EIAs are sensitive and relatively easy to perform. EIA is the preferred testing method for IgM, using the capture technique, although indirect assays are also acceptable. In infants with CRS, IgM antibody can be detected in the infant’s cord blood or serum and persists for about 6–12 months.